Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Philip D. Greenberg"'
Autor:
William Chour, Jongchan Choi, Jingyi Xie, Mary E. Chaffee, Thomas M. Schmitt, Kathryn Finton, Diana C. DeLucia, Alexander M. Xu, Yapeng Su, Daniel G. Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H. C. Ng, Jonah Z. Butler, Rick A. Edmark, Lesley C. Jones, Kim M. Murray, Songming Peng, Guideng Li, Roland K. Strong, John K. Lee, Jason D. Goldman, Philip D. Greenberg, James R. Heath
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput
Externí odkaz:
https://doaj.org/article/3bdea162be0a4447904d5af92d6a6730
Autor:
Young Ho Ban, Se-Chan Oh, Sang-Hwan Seo, Seok-Min Kim, In-Pyo Choi, Philip D. Greenberg, Jun Chang, Tae-Don Kim, Sang-Jun Ha
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2598-2611 (2017)
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockou
Externí odkaz:
https://doaj.org/article/d20d629665504a819430e9c6157aee50
Autor:
Tae-Don Kim, Hong-Ryul Jung, Sang-Hwan Seo, Se-Chan Oh, Youngho Ban, Xiaoxia Tan, Jung Min Kim, Sang Hyun Lee, Duk-Su Koh, Haiyoung Jung, Young-Jun Park, Suk Ran Yoon, Junsang Doh, Sang-Jun Ha, Inpyo Choi, Philip D. Greenberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Regulation of intracellular Ca2+ signaling is a major determinant of CD8+ T cell responsiveness, but the mechanisms underlying this regulation of Ca2+ levels, especially in naïve CD8+ T cells, are not fully defined. Here, we showed that mic
Externí odkaz:
https://doaj.org/article/30c9bb05268048c4babaae073c535db7
Targeting Driver Oncogenes and Other Public Neoantigens Using T Cell Receptor–Based Cellular Therapy
Autor:
Tijana Martinov, Philip D. Greenberg
Publikováno v:
Annual Review of Cancer Biology. 7:331-351
T cell reactivity to tumor-specific neoantigens can drive endogenous and therapeutically induced antitumor immunity. However, most tumor-specific neoantigens are unique to each patient (private) and targeting them requires personalized therapy. A sma
Autor:
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Publikováno v:
Blood Cancer Discov
Autor:
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinéad Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Publikováno v:
Sci Transl Med
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab8910054866ad4b7f3c2247308f44
https://doi.org/10.1126/scitranslmed.abg8070
https://doi.org/10.1126/scitranslmed.abg8070
Autor:
Philip D. Greenberg, Raphael Gottardo, Charles W. Drescher, Ingunn M. Stromnes, Christopher B. Morse, Shannon K. Oda, Nicolas M. Garcia, Madison G. Burnett, Edison Y. Chiu, Breanna M. Bates, Valentin Voillet, Kristin G. Anderson
Figure S2: Engineered murine T cells exhibit effector function in response to cognate peptide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbf43fa751a120f7f60ec30f7643f8c
https://doi.org/10.1158/2326-6066.22543435
https://doi.org/10.1158/2326-6066.22543435
Autor:
Sunil R. Hingorani, Philip D. Greenberg, Robert H. Pierce, Ellen J. Spartz, Jackson F. Raynor, J. Scott Brockenbrough, Cheryl Black, Patrick Bonson, Ayaka Hulbert, Adam L. Burrack, Ingunn M. Stromnes
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3889d98b8d31697f6a7b46d07e3a0c8
https://doi.org/10.1158/2326-6066.22542532
https://doi.org/10.1158/2326-6066.22542532
Autor:
Philip D. Greenberg, Raphael Gottardo, Charles W. Drescher, Ingunn M. Stromnes, Christopher B. Morse, Shannon K. Oda, Nicolas M. Garcia, Madison G. Burnett, Edison Y. Chiu, Breanna M. Bates, Valentin Voillet, Kristin G. Anderson
Figure Legends for Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975efb2816191d40d7b2661b26c8ea6e
https://doi.org/10.1158/2326-6066.22543414.v1
https://doi.org/10.1158/2326-6066.22543414.v1
Autor:
Philip D. Greenberg, Raphael Gottardo, Charles W. Drescher, Ingunn M. Stromnes, Christopher B. Morse, Shannon K. Oda, Nicolas M. Garcia, Madison G. Burnett, Edison Y. Chiu, Breanna M. Bates, Valentin Voillet, Kristin G. Anderson
Adoptive T-cell therapy using high-affinity T-cell receptors (TCR) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02eecee4fe98f8dd53a22107cf78629
https://doi.org/10.1158/2326-6066.c.6550249.v1
https://doi.org/10.1158/2326-6066.c.6550249.v1