Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Philip D Dunne"'
Autor:
Darragh G McArt, Philip D Dunne, Jaine K Blayney, Manuel Salto-Tellez, Sandra Van Schaeybroeck, Peter W Hamilton, Shu-Dong Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66902 (2013)
The advent of next generation sequencing technologies (NGS) has expanded the area of genomic research, offering high coverage and increased sensitivity over older microarray platforms. Although the current cost of next generation sequencing is still
Externí odkaz:
https://doaj.org/article/9229e863c14e4176b6b437805a53bd2d
Autor:
Ashleigh C. Hamilton, Finian J. Bannon, Philip D. Dunne, Jacqueline James, Stephen McQuaid, Ronan T. Gray, Manuel Salto-Tellez, Chris R. Cardwell, Maurice B. Loughrey, Helen G. Coleman
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 347-359 (2023)
Background and Aims: The observed increase in the incidence of early-onset colorectal cancer (EOCRC) is being driven by sporadic cases, but the molecular characteristics of these tumors are not fully understood. Our objective was to investigate the p
Externí odkaz:
https://doaj.org/article/8d691786c5d14cfba3e309cbd980f469
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d890b609d092453794d4b110a230e27b
Autor:
Hannah Egan, Oliver Treacy, Kevin Lynch, Niamh A. Leonard, Grace O’Malley, Eileen Reidy, Aoise O’Neill, Shania M. Corry, Kim De Veirman, Karin Vanderkerken, Laurence J. Egan, Thomas Ritter, Aisling M. Hogan, Keara Redmond, Li Peng, Jenny Che, Wayne Gatlin, Pushpa Jayaraman, Margaret Sheehan, Aoife Canney, Sean O. Hynes, Emma M. Kerr, Philip D. Dunne, Michael E. O’Dwyer, Aideen E. Ryan
Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote tumor progression by enhancing immune cell suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5a9ff18739c6840bf4580074fd3b70
https://biblio.vub.ac.be/vubir/targeting-stromal-cell-sialylation-reverses-t-cellmediated-immunosuppression-in-the-tumor-microenvironment(1322be90-3ac7-43dd-8494-4ed572cf07ad).html
https://biblio.vub.ac.be/vubir/targeting-stromal-cell-sialylation-reverses-t-cellmediated-immunosuppression-in-the-tumor-microenvironment(1322be90-3ac7-43dd-8494-4ed572cf07ad).html
Autor:
Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and
Externí odkaz:
https://doaj.org/article/4cfe33bfecaf449b9233c78e1aecfd67
Autor:
Patrick G. Johnston, Mark Lawler, Daniel B. Longley, Manuel Salto-Tellez, Simon McDade, Sandra Van Schaeybroeck, Maurice Loughrey, Wendy L. Allen, Helen G. Coleman, Paul G. O'Reilly, Darragh G. McArt, Philip D. Dunne
Supplementary figure 1: A +B. Hierarchical clustering of microdissected stromal and epithelial (A) and FACS sorted endothelial, fibroblast, epithelial and leukocyte (B) cell populations using previously published non-epithelial derived gene list conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a4cb37c81ec07b49d2bcc45e7bbdd5
https://doi.org/10.1158/2326-6066.22537445
https://doi.org/10.1158/2326-6066.22537445
Autor:
Aideen E. Ryan, Laurence J. Egan, Thomas Ritter, Philip D. Dunne, Paul Lohan, Niamh A. Leonard, Serika D. Naicker, Kevin Lynch, Oliver Treacy, Grace O'Malley
Characterisation of primary BALB/c MSCs isolated from bone marrow, PD-L1 induction on MSC TNF-TCM is dependent on CT26 NF-κB activity, Validation of scrambled and PD-L1 shRNA transduced Balb/c MSCs - GFP expression and PD-L1 inhibition, Tumour burde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a61c546552ef02c383997114c02e32
https://doi.org/10.1158/2326-6066.22538954.v1
https://doi.org/10.1158/2326-6066.22538954.v1
Autor:
Patrick G. Johnston, Mark Lawler, Daniel B. Longley, Manuel Salto-Tellez, Simon McDade, Sandra Van Schaeybroeck, Maurice Loughrey, Wendy L. Allen, Helen G. Coleman, Paul G. O'Reilly, Darragh G. McArt, Philip D. Dunne
A recent phase II study of patients with metastatic colorectal carcinoma showed that mismatch repair gene status was predictive of clinical response to PD-1–targeting immune checkpoint blockade. Further examination revealed strong correlation betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f9c11360589ba9a5e8faca9910f5d5
https://doi.org/10.1158/2326-6066.c.6548450.v1
https://doi.org/10.1158/2326-6066.c.6548450.v1