Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Philip D, Marsh"'
Autor:
Ricardo Costeira, Joseph Aduse-Opoku, Jon J. Vernon, Francisco Rodriguez-Algarra, Susan Joseph, Deirdre A. Devine, Philip D. Marsh, Vardhman Rakyan, Michael A. Curtis, Jordana T. Bell
Publikováno v:
mSystems, Vol 8, Iss 4 (2023)
ABSTRACT Periodontal disease is a chronic inflammatory disease in which the oral pathogen Porphyromonas gingivalis plays an important role. Porphyromonas gingivalis expresses virulence determinants in response to higher hemin concentrations, but the
Externí odkaz:
https://doaj.org/article/c5854e0bd0ed43ff85b241856c52a9f6
Autor:
Divyashri Baraniya, Thuy Do, Tsute Chen, Jasim M. Albandar, Susan M. Chialastri, Deirdre A. Devine, Philip D. Marsh, Nezar N. Al-Hebshi
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Modeling subgingival microbiome in health and disease is key to identifying the drivers of dysbiosis and to studying microbiome modulation. Here, we optimize growth conditions of our previously described in vitro subgingival microbiome model. Subging
Externí odkaz:
https://doaj.org/article/8c8133881e864b26bd007e640b924256
Autor:
Laura Sibley, Andrew D. White, Karen E. Gooch, Lisa M. Stevens, Rachel Tanner, Ashley Jacobs, Owen Daykin-Pont, Fergus Gleeson, Anthony McIntyre, Randall Basaraba, Simon Clark, Graham Hall, Geoff Pearson, Emma Rayner, Helen McShane, Ann Williams, Mike Dennis, Philip D. Marsh, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three
Externí odkaz:
https://doaj.org/article/012f7b94a99f4b9a8b55500c6bbff3f8
Autor:
Charlotte Sarfas, Andrew D. White, Laura Sibley, Alexandra L. Morrison, Jennie Gullick, Steve Lawrence, Mike J. Dennis, Philip D. Marsh, Helen A. Fletcher, Sally A. Sharpe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In many countries where tuberculosis (TB) is endemic, the Bacillus Calmette–Guérin (BCG) vaccine is given as close to birth as possible to protect infants and children from severe forms of TB. However, BCG has variable efficacy and is not as effec
Externí odkaz:
https://doaj.org/article/23a524431d8548a983dc1bcc98994a67
Publikováno v:
Molecular Oral Microbiology. 37:122-132
The periodontal pathogen Porphyromonas gingivalis is genetically heterogeneous. However, the spontaneous generation of phenotypically different sub-strains has also been reported. McKee et al. (1988) cultured P. gingivalis W50 in a chemostat during i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c59598f451688fe2fecd2a4b5ae468
https://doi.org/10.1111/omi.12373
https://doi.org/10.1111/omi.12373
Publikováno v:
Journal of Oral Microbiology, Vol 7, Iss 0, Pp 1-4 (2015)
Immunomodulatory commensal bacteria are proposed to be essential for maintaining healthy tissues, having multiple roles including priming immune responses to ensure rapid and efficient defences against pathogens. The default state of oral tissues, li
Externí odkaz:
https://doaj.org/article/1dc9b6ec40b34dc6a14b874513896d96
Publikováno v:
Journal of Oral Microbiology, Vol 6, Iss 0, Pp 1-4 (2014)
The mouth supports a diverse microbiota which provides major benefits to the host. On occasions, this symbiotic relationship breaks down (dysbiosis), and disease can be a consequence. We argue that progress in the control of oral diseases will depend
Externí odkaz:
https://doaj.org/article/a668f0251a9748ec80dceafc904a68d9
Autor:
Sally A. Sharpe, Philip D. Marsh, Ann Williams, Michael J. Dennis, Alice Marriott, Andrew D. White, Laura S. Sibley
Publikováno v:
Cells, Vol 1, Iss 1, Pp 5-14 (2012)
Tuberculosis is a global health problem. The Mycobacterium bovis Bacille Calmette Guerin (BCG) vaccine has variable efficacy (0–80%) so there is a drive to develop novel vaccines. The cytokine, interferon gamma (IFNγ), is an essential component of
Externí odkaz:
https://doaj.org/article/9754b01d3a0c4035950f279a8281d8a9
Autor:
Rose E Jeeves, Alice A N Marriott, Steven T Pullan, Kim A Hatch, Jon C Allnutt, Irene Freire-Martin, Charlotte L Hendon-Dunn, Robert Watson, Adam A Witney, Richard H Tyler, Catherine Arnold, Philip D Marsh, Timothy D McHugh, Joanna Bacon
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138253 (2015)
An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M. tuberculosis population there is a proportion of bac
Externí odkaz:
https://doaj.org/article/b77774f4b89f45aa86fd10187fd3db40
Autor:
Philip D. Marsh
Publikováno v:
British Dental Journal. 233:400-400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8fe40102b2b58ff3baa47ec9d8a5ffc
https://doi.org/10.1038/s41415-022-5001-4
https://doi.org/10.1038/s41415-022-5001-4