Zobrazeno 1 - 10
of 746
pro vyhledávání: '"Philip Cohen"'
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss 1 (2023)
Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a
Externí odkaz:
https://doaj.org/article/c92e6312a63543708b07becc97dd9975
Autor:
Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap, we used a combinati
Externí odkaz:
https://doaj.org/article/612ab4473bc34e1f9a8c8690879295a3
Autor:
Philip Cohen
Publikováno v:
Social Determinants of Health, Vol 8, Iss 1 (2022)
Background: Wearing high-heeled shoes is associated with injury risk. During the COVID-19 pandemic, changes in work and social behavior may have reduced women’s use of such footwear. The aim of the study was to investigate how the trend in high-hee
Externí odkaz:
https://doaj.org/article/d973e265bff3475194008e6cee83eea8
Autor:
Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express n
Externí odkaz:
https://doaj.org/article/9aa94b8e1ece4432939106c9866a2b7e
Autor:
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/c56070943eee409893dfc8b9a45018c9
Autor:
Rami Obaid, Sachin E. Wani, Asim Azfer, Toby Hurd, Ruth Jones, Philip Cohen, Stuart H. Ralston, Omar M.E. Albagha
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1096-1102 (2015)
Paget’s disease of bone (PDB) is a common disease characterized by osteoclast activation that leads to various skeletal complications. Susceptibility to PDB is mediated by a common variant at the optineurin (OPTN) locus, which is associated with re
Externí odkaz:
https://doaj.org/article/68dde2ca864b421484e82bf73b442e78
Autor:
Yann Thomas, Daniel C Scott, Yosua Adi Kristariyanto, Jesse Rinehart, Kristopher Clark, Philip Cohen, Thimo Kurz
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199197 (2018)
The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is highly expressed in immune tissue. Here, we provide evidence that DCNL5
Externí odkaz:
https://doaj.org/article/3f989371c22b411cb33e0d7bacb27014
Autor:
Nicolas Dzamko, Francisco Inesta-Vaquera, Jiazhen Zhang, Chengsong Xie, Huaibin Cai, Simon Arthur, Li Tan, Hwanguen Choi, Nathanael Gray, Philip Cohen, Patrick Pedrioli, Kristopher Clark, Dario R Alessi
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39132 (2012)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. LRRK2 is highly expressed in immune cells and recent work points towards a link between LRRK2 and innate immunity. Here
Externí odkaz:
https://doaj.org/article/bc7785f27b4c46faa025687a64c79f6f
Autor:
Philip, Cohen
Publikováno v:
IUBMB Life. 75:284-288
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
Publikováno v:
Biochemical Journal. 479:1891-1907
A conditional knock-in mouse was generated in which the TAK1 catalytic subunit was largely replaced by the kinase-inactive TAK1[D175A] mutant in immune cells. The activation of p38α MAP kinase, c-Jun N-terminal kinases 1 and 2 (JNK1/2) and the canon