Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Philip Chiu Tsun Tang"'
Autor:
Jane Siu-Fan Li, Philip Chiu-Tsun Tang, Chun Kit K. Choi, Alex Siu-Wing Chan, Calvin Sze-Hang Ng, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102823- (2024)
Summary: Immunodynamics in the tumor microenvironment can be precisely examined by using multiple antigen identification approaches. Here, we present a protocol for capturing expression levels of multiple target proteins in the same specimen at singl
Externí odkaz:
https://doaj.org/article/cd4afc4f3ab7487fb859f4714d8f1397
Autor:
Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Jeff Yat‐Fai Chung, Alex Siu‐Wing Chan, Dongmei Zhang, Chunjie Li, Kam‐Tong Leung, Calvin Sze‐Hang Ng, Yi Wu, Ka‐Fai To, Hui‐Yao Lan, Patrick Ming‐Kuen Tang
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung carcinoma (NSCLC) in a TGF‐β1/Smad3 dependent manner. Better un
Externí odkaz:
https://doaj.org/article/87ee915054aa49ad8d44d285ae662e18
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Vivian Weiwen Xue, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Travis Hoi-Wai To, Justin Shing-Yin Chung, Francis Mussal, Eric W.-F. Lam, Chunjie Li, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 26-37 (2021)
Mincle is essential for tumor-associated macrophage (TAM)-driven cancer progression and represents a potential immunotherapeutic target for cancer. Nevertheless, the lack of a specific inhibitor has largely limited its clinical translation. Here, we
Externí odkaz:
https://doaj.org/article/1ce12fdf1f614834a957f8ffa6de827e
Autor:
Philip Chiu‐Tsun Tang, Jeff Yat‐Fai Chung, Vivian Wei‐wen Xue, Jun Xiao, Xiao‐Ming Meng, Xiao‐Ru Huang, Shuang Zhou, Alex Siu‐Wing Chan, Anna Chi‐Man Tsang, Alfred Sze‐Lok Cheng, Tin‐Lap Lee, Kam‐Tong Leung, Eric W.‐F. Lam, Ka‐Fai To, Patrick Ming‐Kuen Tang, Hui‐Yao Lan
Publikováno v:
Advanced Science, Vol 9, Iss 1, Pp n/a-n/a (2022)
Abstract Cancer‐associated fibroblasts (CAFs) are important in tumor microenvironment (TME) driven cancer progression. However, CAFs are heterogeneous and still largely underdefined, better understanding their origins will identify new therapeutic
Externí odkaz:
https://doaj.org/article/88a2b3b2105e4c93a1fe6c6dfeb41b23
Autor:
Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Cai-Bin Zhang, Cristina Alexandra García Córdoba, Ying-Ying Zhang, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic strategies are yet available due to their elusive pathogenic mechanisms. CKD
Externí odkaz:
https://doaj.org/article/8fec8298e69449439ed9f77520c40e9c
Autor:
Philip Chiu-Tsun Tang, Ying-Ying Zhang, Jane Siu-Fan Li, Max Kam-Kwan Chan, Jiaoyi Chen, Ying Tang, Yiming Zhou, Dongmei Zhang, Kam-Tong Leung, Ka-Fai To, Sydney Chi-Wai Tang, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Non-Coding RNA, Vol 8, Iss 3, p 36 (2022)
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibr
Externí odkaz:
https://doaj.org/article/54e6ce1d99cf439fa1f40b6f1d388ae0
Publikováno v:
Non-coding RNA Research, Vol 2, Iss 1, Pp 68-73 (2017)
Transforming growth factor-β1 (TGF-β1) has an essential role in the development of kidney diseases. However, targeting TGF-β1 is not a good strategy for fibrotic diseases due to its multifunctional characteristic in physiology. A precise the
Externí odkaz:
https://doaj.org/article/f67e1aaa78914208a0d119f1c685199f
Autor:
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze-Hang Ng, Eric W-F Lam, Dongmei Zhang, Yi-Ping Ho, Ka-Fai To, Kam-Tong Leung, Xiaohua Jiang, Ho Ko, Tin-Lap Lee, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Science Advances. 8
Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753232f8bf62da81a03d05ebceacc683
https://doi.org/10.1126/sciadv.abn5535
https://doi.org/10.1126/sciadv.abn5535
Autor:
Philip Chiu-Tsun Tang, Ka Fai To, Chunjie Li, Hui-Yao Lan, Patrick Ming-Kuen Tang, Alex Siu Wing Chan, Francis Mussal, Eric W.-F. Lam, Jeff Yat-Fai Chung, Kam Tong Leung, Travis Hoi-Wai To, Vivian Weiwen Xue, Justin Shing-Yin Chung
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 26-37 (2021)
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 26-37 (2021)
Mincle is essential for tumor-associated macrophage (TAM)-driven cancer progression and represents a potential immunotherapeutic target for cancer. Nevertheless, the lack of a specific inhibitor has largely limited its clinical translation. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc437733cad50cbd4c0c435a1904d2b1
http://europepmc.org/articles/PMC8463747
http://europepmc.org/articles/PMC8463747