Výsledky vyhledávání - "Philip Catlin"

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels

Autor: Philip Catlin, Baldomero M. Olivera, Jeffrey R. McArthur, Layla Azam, Doju Yoshikami, Brian Fiedler, Heinrich Terlau, Raymond S. Norton, Grzegorz Bulaj, Brian J. Smith, Jean Rivier, Min Min Zhang, Ashley R. Chadwick, Robert J. French, Brad R. Green, Josef Gulyas

Publikováno v: The Journal of biological chemistry. 282(42)

Peptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic conotoxins have already reached human clinical trials, a continuing need exists for the discovery and development of novel non-op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbeb901256e30fe0b168d00e762a3d06
https://pubmed.ncbi.nlm.nih.gov/17724025

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Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity

Autor: Doju Yoshikami, Grzegorz Bulaj, Brian Fiedler, Baldomero M. Olivera, Brad R. Green, Raymond S. Norton, Alex Morrison, Brian J. Smith, Philip Catlin, Min Min Zhang, Wendi Bayudan

Publikováno v: Chemistrybiology. 14(4)

SummaryDisulfide-rich neurotoxins from venomous animals continue to provide compounds with therapeutic potential. Minimizing neurotoxins often results in removal of disulfide bridges or critical amino acids. To address this drug-design challenge, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df69e8cd2ebc1a031242029022448b9
https://pubmed.ncbi.nlm.nih.gov/17462575

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