Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Philip Carthew"'
Autor:
Lutz Edler, Gary M. Williams, Andy Hart, Alan R. Boobis, B. Smith, Myriam Coulet, Philip Carthew, Peter Greaves
Publikováno v:
Food and Chemical Toxicology. 70:264-289
This article addresses a number of concepts related to the selection and modelling of carcinogenicity data for the calculation of a Margin of Exposure. It follows up on the recommendations put forward by the International Life Sciences Institute - Eu
Autor:
Tyra Leazer, Linda Loretz, George P. Daston, David Schreur, Alan M. Hoberman, Peter Mann, Philip Carthew, Thomas Re
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 83:123-133
BACKGROUND: Parabens are widely used preservatives in cosmetics and pharmaceutical products, and approved as food additives. Parabens have been considered safe for these uses for many years. Recently, adverse effects on male reproductive parameters i
Publikováno v:
Inhalation Toxicology. 18:227-245
The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study.
Publikováno v:
Inhalation Toxicology. 14:401-416
The methods involved in the safety assessment of resins used in hair-spray products have received little peer review, or debate in the published literature, despite their widespread use, in both hairdressing salons and the home. The safety assessment
Autor:
Elizabeth A. Martin, Robert T. Heydon, Philip Carthew, Peter N. Lee, R.E. Edwards, B.M. Nolan
Publikováno v:
Archives of Toxicology. 75:375-380
Tamoxifen is a potent rat liver carcinogen, currently being used as a long-term chemopreventative for breast cancer in healthy women. The mechanism by which tamoxifen causes liver cancer in rats is known to be associated with the accumulation of tamo
Autor:
Reginald Davies, Karen Brown, Lewis L. Smith, Elizabeth A. Martin, John E. Brown, Philip Carthew, Ian N.H. White, Jerry Styles
Publikováno v:
Carcinogenesis. 22:553-557
It is now generally accepted that activation of tamoxifen occurs as a result of metabolism to alpha-hydroxytamoxifen. In this study, alpha-hydroxytamoxifen was given to female Wistar/Han rats (0.103 or 0.0103 mmol/kg, intraperitoneally, daily for 5 d
Publikováno v:
Toxicological Sciences. 44:46-51
Publikováno v:
Carcinogenesis. 14:1381-1387
Female F344 rats received an i.p. injection of iron-dextran (600 mg Fe/kg) and then after 1 week were fed a diet containing 0.02% hexachlorobenzene (HCB) for up to 65 weeks. All rats (8/8) which received HCB after iron overload developed multiple hep
Publikováno v:
Human & Experimental Toxicology. 11:530-534
1 The dose—response data for the induction of mesothelioma, in rats, by the intrapleural administration of the fibrous zeolite, erionite, has been compared to the published data for the crocidolite and chrysotile forms of asbestos. Erionite is more
Publikováno v:
Carcinogenesis. 13:1917-1920
C57BL/10ScSn mice administered iron--dextran and fed the environmental pollutants hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) develop hepatic nodules and carcinomas within 18 months. A range of lesions from the livers were analysed f