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Publikováno v:
Biochemical Pharmacology. 59:161-165
N-[(2'-Dimethylamino)ethyl]acridine-4-carboxamide (DACA) is a new anticancer agent currently undergoing clinical trials. The metabolism of DACA to acridone metabolites by aldehyde oxidase (AO) (EC 1.2.3.1) appears to play a major role in its eliminat
Autor:
Michael R. McCrystal, James W. Paxton, Iain G. C. Robertson, Philip C. Schofield, Philip Kestell, Barrie D. Evans, Bruce C. Baguley
Publikováno v:
Cancer chemotherapy and pharmacology. 44(1)
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA) is an experimental antitumour agent that has just completed phase I clinical trials in New Zealand and the United Kingdom. Urine (0–72 h) was analysed from 20 patients receiving DACA infused o