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pro vyhledávání: '"Philip C. Hanawalt"'
Autor:
Philip C. Hanawalt
Publikováno v:
Life, Vol 13, Iss 4, p 1052 (2023)
This article recounts my graduate research at Yale University (1954–1958) on unbalanced growth in Eschericia coli during thymine deprivation or following ultraviolet (UV) irradiation, with early evidence for the repair of UV-induced DNA damage. Fol
Externí odkaz:
https://doaj.org/article/12fcf82d8ee2472389b3b9c618f36332
Autor:
Philip C. Hanawalt
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
The early history of the esoteric phenomenon of thymineless death (TLD) is recounted, from the pioneering discovery by Seymour Cohen and Hazel Barner, through my graduate studies at Yale and postdoctoral research in Copenhagen. My principal contribut
Externí odkaz:
https://doaj.org/article/52fff11373be4333b5de11c4969a0521
Publikováno v:
Biophysical Journal. 121:3345-3357
R-loops are structures containing an RNA-DNA duplex and an unpaired DNA strand. They can be formed upon "invasion" of an RNA strand into a DNA duplex, during which the RNA displaces the homologous DNA strand and binds the complementary strand. R-loop
Autor:
Joann B. Sweasy, Philip C. Hanawalt
Publikováno v:
Environmental and Molecular Mutagenesis. 61:25-33
Within the past half century we have learned of multiple pathways for repairing damaged DNA, based upon the intrinsic redundancy of information in its complementary double strands. Mechanistic details of these pathways have provided insights into env
Publikováno v:
DNA Repair. 110:103275
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2105
R-loops are structures consisting of an RNA-DNA duplex and an unpaired DNA strand. They can form during transcription upon nascent RNA "threadback" invasion into the DNA duplex to displace the non-template DNA strand. R-loops occur naturally in all k
Publikováno v:
Peptide Nucleic Acids ISBN: 9781071602423
R-loops are structures consisting of an RNA-DNA duplex and an unpaired DNA strand. They can form during transcription upon nascent RNA "threadback" invasion into the DNA duplex to displace the non-template DNA strand. R-loops occur naturally in all k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8859f0b757b70e27933211d9a5fea6a7
https://doi.org/10.1007/978-1-0716-0243-0_8
https://doi.org/10.1007/978-1-0716-0243-0_8
Publikováno v:
PLoS Genetics, Vol 6, Iss 3, p e1000865 (2010)
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine. Despite its being the essential mode of action of important chemotherapeuti
Externí odkaz:
https://doaj.org/article/2887138b44fb481892b7720cf225765e
Publikováno v:
DNA Repair. 104:103138
Publikováno v:
Nucleic Acids Research
Guanine-rich (G-rich) homopurine–homopyrimidine nucleotide sequences can block transcription with an efficiency that depends upon their orientation, composition and length, as well as the presence of negative supercoiling or breaks in the non-templ