Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Philip C. Burcham"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 108:106957
Introduction While cysteine thiol groups help to maintain the redox status of many proteins, they can be very susceptible to damaging oxidants. Despite broad interest in their antioxidant properties, whether tea polyphenols protect against protein th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90254ccbd56f292f3555c538a3735001
https://doi.org/10.1016/j.vascn.2021.106957
https://doi.org/10.1016/j.vascn.2021.106957
Autor:
Philip C. Burcham
Publikováno v:
Chemical Research in Toxicology. 30:145-161
Acrolein is a highly toxic electrophile that participates in many diseases, yet efforts to delineate its precise mechanistic contributions to specific conditions are complicated by its wide distribution within human environments. This Perspective dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f86e3c247c1e1e3d42044285c15d825
https://doi.org/10.1021/acs.chemrestox.6b00310
https://doi.org/10.1021/acs.chemrestox.6b00310
Autor:
Philip C. Burcham
Publikováno v:
Biochemical pharmacology. 154
During cellular metabolism, spontaneous oxidative damage to unsaturated lipids generates many electrophilic carbonyl compounds that readily attack cell macromolecules, forming adducts that are potential drivers of tissue dysfunction. Since such damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fc12aeee3b23e6ad40ff3626b77b2c
https://pubmed.ncbi.nlm.nih.gov/29883705
https://pubmed.ncbi.nlm.nih.gov/29883705
Autor:
Simon Ching, Arthur W. Musk, Philip C. Burcham, Helman Alfonso, David A. Joyce, Nola Olsen, Peter Franklin, Kevin D. Croft, Nicholas de Klerk, Alison Reid
Publikováno v:
Respirology. 20:1102-1107
Background and objective Many of the pathological consequences in the lung following inhalation of asbestos fibres arise as a consequence of persistent oxidative stress and inflammation. Inflammatory responses can be observed in asymptomatic asbestos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12e1ea04c3d6aa177bc4c015f844c10f
https://doi.org/10.1111/resp.12592
https://doi.org/10.1111/resp.12592
Publikováno v:
Biochemical Pharmacology. 93:519-526
The airway epithelium is an important source of relaxant mediators, and damage to the epithelium caused by respiratory tract viruses may contribute to airway hyperreactivity. The aim of this study was to determine whether influenza A-induced epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e498412ed34d8ded5e1cc48e27ed1c85
https://doi.org/10.1016/j.bcp.2014.12.015
https://doi.org/10.1016/j.bcp.2014.12.015
Autor:
Philip C. Burcham
General levels of “pharmaceuticals literacy” are not high in contemporary societies. To address this educational need, in 2012 the University of Western Australia introduced an innovative multidisciplinary course for undergraduates within any deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772a94154d6aad2282444f8fc91545bc
https://europepmc.org/articles/PMC5512121/
https://europepmc.org/articles/PMC5512121/
Autor:
Philip C. Burcham
Publikováno v:
Christian Bioethics. 20:359-375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e35bb60ecf7a3adfa5ecdccfbb2a9f84
https://doi.org/10.1093/cb/cbu027
https://doi.org/10.1093/cb/cbu027
Publikováno v:
Biochemical Pharmacology. 89:148-156
Airway sensory C-fibres express TRPA1 channels which have recently been identified as a key chemosensory receptor for acrolein, a toxic and highly prevalent component of smoke. TRPA1 likely plays an intermediary role in eliciting a range of effects i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9902642e1596f4622ff3b09a2bbfe909
https://doi.org/10.1016/j.bcp.2014.02.009
https://doi.org/10.1016/j.bcp.2014.02.009
Publikováno v:
Toxicology Letters. 212:241-251
The combustion product acrolein contributes to several smoke-related health disorders, but whether this immunomodulatory toxicant alters pulmonary susceptibility to viruses has received little attention. To study the effects of prior acrolein dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c26a600ed9d56eb3619f03584cb131
https://doi.org/10.1016/j.toxlet.2012.06.003
https://doi.org/10.1016/j.toxlet.2012.06.003
Publikováno v:
Chemico-Biological Interactions. 183:416-424
The noxious 3-carbon electrophile acrolein forms on combustion of diverse organic matter including synthetic polymers such as polyethylene. While known to play a key role in smoke inhalation injury (SII), the molecular basis for the pulmonary toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5da285fc311199887e70f56675fe96
https://doi.org/10.1016/j.cbi.2009.12.006
https://doi.org/10.1016/j.cbi.2009.12.006