Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Philip Brownridge"'
Autor:
Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, Philip Brownridge, Dominic P. Bryne, Leonard A. Daly, Arturas Grauslys, Marius Walter, Fabrice Agou, Lisa A. Chakrabarti, Charles S. Craik, Claire E. Eyers, Patrick A. Eyers, Yann Gambin, Andrew R. Jones, Emma Sierecki, Eric Verdin, Marco Vignuzzi, Edward Emmott
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular p
Externí odkaz:
https://doaj.org/article/09cd9fa5dad54609b514710cffa2869d
Autor:
Tuomas Huokko, Tao Ni, Gregory F. Dykes, Deborah M. Simpson, Philip Brownridge, Fabian D. Conradi, Robert J. Beynon, Peter J. Nixon, Conrad W. Mullineaux, Peijun Zhang, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cyanobacterial thylakoid membranes host the molecular machinery for the light-dependent reactions of photosynthesis and respiratory electron flow. Here, the authors show that newly synthesized thylakoids emerge between the plasma membrane and pre-exi
Externí odkaz:
https://doaj.org/article/e81caaf209894fb39e6d7cc159558962
Autor:
Mengru Yang, Deborah M. Simpson, Nicolas Wenner, Philip Brownridge, Victoria M. Harman, Jay C. D. Hinton, Robert J. Beynon, Lu-Ning Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Enteric pathogens such as Salmonella depend on propanediol-utilising microcompartments (Pdu MCP), which self-assemble from cytosolic proteins. Using mass spectrometry-based absolute quantification, the authors here define the protein stoichiometry an
Externí odkaz:
https://doaj.org/article/b8d56250827a4705bb5c667f33be65dc
Autor:
Emma C. Wall, Philip Brownridge, Gavin Laing, Vanessa S. Terra, Veronica Mlozowa, Brigitte Denis, Mulinda Nyirenda, Theresa Allain, Elisa Ramos-Sevillano, Enitan Carrol, Andrea Collins, Stephen B. Gordon, David G. Lalloo, Brendan Wren, Robert Beynon, Robert S. Heyderman, Jeremy S. Brown
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
BackgroundMortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae, exceeds 50% in sub-Saharan African countries with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host an
Externí odkaz:
https://doaj.org/article/163e0ab026b9423982b15ade154fdfc2
Autor:
Rocío Canals, Disa L Hammarlöf, Carsten Kröger, Siân V Owen, Wai Yee Fong, Lizeth Lacharme-Lora, Xiaojun Zhu, Nicolas Wenner, Sarah E Carden, Jared Honeycutt, Denise M Monack, Robert A Kingsley, Philip Brownridge, Roy R Chaudhuri, Will P M Rowe, Alexander V Predeus, Karsten Hokamp, Melita A Gordon, Jay C D Hinton
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000059 (2019)
Salmonella Typhimurium sequence type (ST) 313 causes invasive nontyphoidal Salmonella (iNTS) disease in sub-Saharan Africa, targeting susceptible HIV+, malarial, or malnourished individuals. An in-depth genomic comparison between the ST313 isolate D2
Externí odkaz:
https://doaj.org/article/31ec980307d14f1684f15b5ba899d49a
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 344-348 (2015)
The data provides information in support of the research article, “Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging”, Journal of Proteome Research, 2014, 13 (11), 2008–2
Externí odkaz:
https://doaj.org/article/2a6d01308a6048ce93cdfd8f25b76bba
Autor:
Jeff W. Barclay, Claire E. Eyers, Alan Morgan, Kimberley Burrow, Richard Campion, Patricia Thomas, Philip Brownridge, Leanne Bloxam, Campbell W. Gourlay, Daniel R Pentland
Publikováno v:
Biochemical Journal
BIOCHEMICAL JOURNAL
BIOCHEMICAL JOURNAL
Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways, such as TOR, are strongly lin
Autor:
Claire E. Eyers, Lauren J. Tomlinson, Dominic P. Byrne, Joscelyn Sarsby, Matthew Bachelor, Richard Bayliss, Philip Brownridge, Patrick A. Eyers
Publikováno v:
Journal of the American Society for Mass Spectrometry
Protein kinase inhibitors are proving highly effective in helping treat a number of non-communicable diseases driven by aberrant kinase signaling. They are also extremely valuable as chemical tools to help delineate cellular roles of kinase signaling
Autor:
Catarina Franco, Robert J. Beynon, Paula Stockley, Amanda J. Davidson, Dean E. Hammond, Philip Brownridge, Amy J. Claydon, Jane L. Hurst
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of USA
Proceedings of the National Academy of Sciences of USA
Significance Promiscuous mating by females leads to competition between males for fertilization success. When fertilization is internal, this means that rival males’ sperm must compete within the female reproductive tract to reach the eggs. Males o
Autor:
Jeanne Chiaravalli, Marius Walter, Edward Emmott, Emma Sierecki, Stacy Gellenoncourt, Philip Brownridge, Arturas Grauslys, Andrew R. Jones, Fabrice Agou, Charles S. Craik, Marco Vignuzzi, Yann Gambin, Patrick A. Eyers, Lisa A. Chakrabarti, Eric Verdin, Leonard A. Daly, Bjoern Meyer, Dominic P. Bryne, Claire E. Eyers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, 2021, 12 (1), pp.5553. ⟨10.1038/s41467-021-25796-w⟩
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, 2021, 12 (1), pp.5553. ⟨10.1038/s41467-021-25796-w⟩
Nature communications, vol 12, iss 1
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and vaccinate against this pathogen all benefit from an improved understanding