Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Philip Britz-McKibbin"'
Autor:
Katie O’Hearn, Kusum Menon, Lisa Albrecht, Karin Amrein, Philip Britz-McKibbin, Florence Cayouette, Karen Choong, Jennifer Ruth Foster, Dean A. Fergusson, Alejandro Floh, Patricia Fontela, Pavel Geier, Elaine Gilfoyle, Gonzalo Garcia Guerra, Anna Gunz, Erick Helmeczi, Ali Khamessan, Ari R. Joffe, Laurie Lee, Lauralyn McIntyre, Srinivas Murthy, Simon J. Parsons, Tim Ramsay, Lindsay Ryerson, Marisa Tucci, Dayre McNally, the Canadian Critical Care Trials Group
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background The rate of vitamin D deficiency (VDD) in critically ill children worldwide has been estimated at 50%. These children are at risk of multiple organ dysfunction, chronic morbidity, and decreased health related quality of life (HRQL
Externí odkaz:
https://doaj.org/article/40ecd62e39304633b75bfcc314fd918c
Autor:
Tomás Clive Barker-Tejeda, Elisa Zubeldia-Varela, Andrea Macías-Camero, Lola Alonso, Isabel Adoración Martín-Antoniano, María Fernanda Rey-Stolle, Leticia Mera-Berriatua, Raphaëlle Bazire, Paula Cabrera-Freitag, Meera Shanmuganathan, Philip Britz-McKibbin, Carles Ubeda, M. Pilar Francino, Domingo Barber, María Dolores Ibáñez-Sandín, Coral Barbas, Marina Pérez-Gordo, Alma Villaseñor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early
Externí odkaz:
https://doaj.org/article/bce91622561c4bab9562e96f74ef59be
Autor:
Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad, Elinor Simons, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Philip Britz-McKibbin, Sonia S Anand
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Childhood obesity is a global health concern and can lead to lifetime cardiometabolic disease. New advances in metabolomics can provide biochemical insights into the early development of obesity, so we aimed to characterize serum
Externí odkaz:
https://doaj.org/article/af6d3e803bc74e65ac64b8014ecf71fc
Autor:
Ritchie Ly, Brittany C. MacIntyre, Stuart M. Philips, Chris McGlory, David M. Mutch, Philip Britz-McKibbin
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100445- (2023)
Optimal dietary intake of omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFAs) is critical to human health across the lifespan. However, omega-3 index (O3I) determination is not routinely assessed due to complicated procedures for n3-LCPUFA an
Externí odkaz:
https://doaj.org/article/81360f8065254cea869d070ef8691d17
Autor:
Talha Rafiq, Jennifer C. Stearns, Meera Shanmuganathan, Sandi M. Azab, Sonia S. Anand, Lehana Thabane, Joseph Beyene, Natalie C. Williams, Katherine M. Morrison, Koon K. Teo, Philip Britz-McKibbin, Russell J. de Souza
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16651- (2023)
Evidence supports a complex interplay of gut microbiome and host metabolism as regulators of obesity. The metabolic phenotype and microbial metabolism of host diet may also contribute to greater obesity risk in children early in life. This study aime
Externí odkaz:
https://doaj.org/article/6ed42faccc7d40a695c21969a3a1dc57
Autor:
Brittany C. MacIntyre, Meera Shanmuganathan, Shannon L. Klingel, Zachary Kroezen, Erick Helmeczi, Na-Yung Seoh, Vanessa Martinez, Adrian Chabowski, Zeny Feng, Philip Britz-McKibbin, David M. Mutch
Publikováno v:
Metabolites, Vol 13, Iss 10, p 1071 (2023)
The Omega-3 Index (O3I) reflects eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) content in erythrocytes. While the O3I is associated with numerous health outcomes, its widespread use is limited. We investigated whether urinary metabolites
Externí odkaz:
https://doaj.org/article/b8e4897cd64c4913a62d68856c4b1663
Autor:
Sandi M. Azab, Russell J. de Souza, Amel Lamri, Meera Shanmuganathan, Zachary Kroezen, Karleen M. Schulze, Dipika Desai, Natalie C. Williams, Katherine M. Morrison, Stephanie A. Atkinson, Koon K. Teo, Philip Britz-McKibbin, Sonia S. Anand
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Defining the metabolic syndrome (MetS) in children remains challenging. Furthermore, a dichotomous MetS diagnosis can limit the power to study associations. We sought to characterize the serum metabolite signature of the MetS in e
Externí odkaz:
https://doaj.org/article/8cf6b0dcf3f141f289bb4946e79559f3
Autor:
Erick Helmeczi, Eric Fries, Lauren Perry, Karen Choong, Katie O’Hearn, Dayre McNally, Philip Britz-McKibbin
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 5, Pp 100204- (2022)
Vitamin D is an important fat-soluble prohormone with pleiotropic effects on human health, such as immunomodulation of the innate and adaptive immune system. There is an unmet clinical need for a rapid screening platform for 25-hydroxyvitamin D (25OH
Externí odkaz:
https://doaj.org/article/622d00d8ea4b4538bfbb52ff6838cfeb
Autor:
Russell J de Souza, Milan Gupta, Koon Teo, Sonia S Anand, Dipika Desai, Claudia Sikorski, Sandi Azab, Meera Shanmuganathan, Stephanie A Atkinson, Katherine Morrison, Philip Britz-McKibbin
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 10, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/535bab961a6347ff89aba368cfaeac79
Autor:
Sandi M. Azab, Russell J. de Souza, Koon K. Teo, Sonia S. Anand, Natalie C. Williams, Jordan Holzschuher, Chris McGlory, Stuart M. Philips, Philip Britz-McKibbin
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 933-944 (2020)
Nutritional studies rely on various biological specimens for FA determination, yet it is unclear how levels of serum NEFAs correlate with other circulating lipid pools. Here, we used a high-throughput method (
Externí odkaz:
https://doaj.org/article/499360a3b4a5475bbb28c1239e61c8f2