Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Philip Bradley"'
Autor:
Lindsey A. Doyle, Brittany Takushi, Ryan D. Kibler, Lukas F. Milles, Carolina T. Orozco, Jonathan D. Jones, Sophie E. Jackson, Barry L. Stoddard, Philip Bradley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract De novo protein design methods can create proteins with folds not yet seen in nature. These methods largely focus on optimizing the compatibility between the designed sequence and the intended conformation, without explicit consideration of
Externí odkaz:
https://doaj.org/article/c5879c95398e49c699dcc9e8f2ec0118
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011664 (2023)
T cells rely on their T cell receptors (TCRs) to discern foreign antigens presented by human leukocyte antigen (HLA) proteins. The TCRs of an individual contain a record of this individual's past immune activities, such as immune response to infectio
Externí odkaz:
https://doaj.org/article/5416700ae9fd4612a1e4c89c9b0c9eee
Publikováno v:
eLife, Vol 12 (2023)
To appropriately defend against a wide array of pathogens, humans somatically generate highly diverse repertoires of B cell and T cell receptors (BCRs and TCRs) through a random process called V(D)J recombination. Receptor diversity is achieved durin
Externí odkaz:
https://doaj.org/article/954f923ab0d24c51b54190fb2b2bfec9
Autor:
Philip Bradley
Publikováno v:
eLife, Vol 12 (2023)
The regulatory and effector functions of T cells are initiated by the binding of their cell-surface T cell receptor (TCR) to peptides presented by major histocompatibility complex (MHC) proteins on other cells. The specificity of TCR:peptide-MHC inte
Externí odkaz:
https://doaj.org/article/15bfd40ed66f46aab0b87f5cb12ac1dc
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010681 (2022)
The complexity of entire T cell receptor (TCR) repertoires makes their comparison a difficult but important task. Current methods of TCR repertoire comparison can incur a high loss of distributional information by considering overly simplistic sequen
Externí odkaz:
https://doaj.org/article/07e08b08cdfd43c5b68f7ac983c2b188
Autor:
Jazmine P. Hallinan, Lindsey A. Doyle, Betty W. Shen, Mesfin M. Gewe, Brittany Takushi, Madison A. Kennedy, Della Friend, James M. Roberts, Philip Bradley, Barry L. Stoddard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jazmine Hallinan et al. report the development of a new generation of circular tandem repeat proteins with enhanced self-assembly. Functionalisation of these constructs with SARS CoV-2 VHH domains resulted in sub-nanomolar binding affinity to the vir
Externí odkaz:
https://doaj.org/article/11aa8d39f41348bfa35c908901de8e41
Autor:
Magdalena L Russell, Aisha Souquette, David M Levine, Stefan A Schattgen, E Kaitlynn Allen, Guillermina Kuan, Noah Simon, Angel Balmaseda, Aubree Gordon, Paul G Thomas, Frederick A Matsen IV, Philip Bradley
Publikováno v:
eLife, Vol 11 (2022)
Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and fun
Externí odkaz:
https://doaj.org/article/95bf64a4fda74d50b1793c5c3f136e61
Autor:
Koshlan Mayer-Blackwell, Stefan Schattgen, Liel Cohen-Lavi, Jeremy C Crawford, Aisha Souquette, Jessica A Gaevert, Tomer Hertz, Paul G Thomas, Philip Bradley, Andrew Fiore-Gartland
Publikováno v:
eLife, Vol 10 (2021)
T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes a
Externí odkaz:
https://doaj.org/article/d1ecb3c26e0145ee974f654e715a1b6d
Autor:
Julia Koehler Leman, Brian D Weitzner, P Douglas Renfrew, Steven M Lewis, Rocco Moretti, Andrew M Watkins, Vikram Khipple Mulligan, Sergey Lyskov, Jared Adolf-Bryfogle, Jason W Labonte, Justyna Krys, RosettaCommons Consortium, Christopher Bystroff, William Schief, Dominik Gront, Ora Schueler-Furman, David Baker, Philip Bradley, Roland Dunbrack, Tanja Kortemme, Andrew Leaver-Fay, Charlie E M Strauss, Jens Meiler, Brian Kuhlman, Jeffrey J Gray, Richard Bonneau
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007507 (2020)
Many scientific disciplines rely on computational methods for data analysis, model generation, and prediction. Implementing these methods is often accomplished by researchers with domain expertise but without formal training in software engineering o
Externí odkaz:
https://doaj.org/article/39b3fd5bfd834abfb5347fc6af6789bc
Autor:
Zachary R. Crook, Gregory P. Sevilla, Della Friend, Mi-Youn Brusniak, Ashok D. Bandaranayake, Midori Clarke, Mesfin Gewe, Andrew J. Mhyre, David Baker, Roland K. Strong, Philip Bradley, James M. Olson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug pote
Externí odkaz:
https://doaj.org/article/68a2dc186894404db175693588126a0e