Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Philip Bidwell"'
1
The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart
Autor: Evangelia G. Kranias, Philip Bidwell, Kobra Haghighi
Publikováno v: Journal of Biological Chemistry. 293:359-367
The antiapoptotic protein HAX-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts with the small membrane protein phospholamban (PLN), inhibiting the cardiac sarco/endoplasmic reticulum calcium ATPase 2a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50351afb51f79859db60bfc5613d9092
https://doi.org/10.1074/jbc.ra117.000128
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2
Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia
Autor: Adam J. Pollak, Sandra E. Wiley, Philip Bidwell, Evangelia G. Kranias, Despina Sanoudou, Kobra Haghighi, Guan-Sheng Liu, Demetrios A. Arvanitis, Vivek P. Singh, Jack E. Dixon, David Gonzalez, Swati Kunduri
Publikováno v: Proceedings of the National Academy of Sciences. 114:9098-9103
Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interacting pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c484eb807a2beb2262085283e6c3563e
https://doi.org/10.1073/pnas.1706441114
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3
Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias
Autor: Erica Vanderbilt, Philip Bidwell, Evangelia G. Kranias, Chi Keung Lam, Roger J. Hajjar, Jianyong Ma, Guan-Sheng Liu, Parthib Das, Kobra Haghighi, Elizabeth Vafiadaki, Tracy J. Pritchard, Vivek P. Singh, Stela Florea, Despina Sanoudou, Jack Rubinstein, Swati Kunduri, Hong Shang Wang
Publikováno v: Journal of Molecular and Cellular Cardiology. 89:349-359
A hallmark of human and experimental heart failure is deficient sarcoplasmic reticulum (SR) Ca-uptake reflecting impaired contractile function. This is at least partially attributed to dephosphorylation of phospholamban by increased protein phosphata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8d65e1d851534e7fc9145cb9d61e26
https://doi.org/10.1016/j.yjmcc.2015.10.004
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4
Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend
Autor: Philip Bidwell, Evangelia G. Kranias, Kobra Haghighi
Publikováno v: Journal of Molecular and Cellular Cardiology. 77:160-167
Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport and Ca-release, is a key and universal characteristic of human and experimental heart failure. These SR processes are regulated by multimeric protein complexes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93f8961cb44602f9985c0ba7ef6f347
https://doi.org/10.1016/j.yjmcc.2014.10.005
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5
HAX-1 regulates SERCA2a oxidation and degradation
Autor: Despina Sanoudou, Djamel Lebeche, Philip Bidwell, Wenfeng Cai, Elizabeth Vafiadaki, Wen Zhao, Guan-Sheng Liu, Roger J. Hajjar, George Gardner, Chi Keung Lam, Jack Rubinstein, Narayani Nagarajan, Kobra Haghighi, Evangelia G. Kranias, Luke Mugge, Junichi Sadoshima
Publikováno v: Journal of molecular and cellular cardiology. 114
Ischemia/reperfusion injury is associated with contractile dysfunction and increased cardiomyocyte death. Overexpression of the hematopoietic lineage substrate-1-associated protein X-1 (HAX-1) has been shown to protect from cellular injury but the fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc191a9b60c58d8dfce4e506b0859358
https://pubmed.ncbi.nlm.nih.gov/29169992
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6
Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance
Autor: Min Jiang, Sheryl E. Koch, Evangelia G. Kranias, Philip Bidwell, Nathan Robbins, W. Keith Jones, Jack Rubinstein, Vinicius Carreira, Amit R. Patel, Valerie M. Lasko, John N. Lorenz, Vivek P. Singh
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 306:H574-H584
Transient receptor potential cation channels have been implicated in the regulation of cardiovascular function, but only recently has our laboratory described the vanilloid-2 subtype (TRPV2) in the cardiomyocyte, though its exact mechanism of action
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2baac409b85c92fa09ea5439ff5f1c
https://doi.org/10.1152/ajpheart.00854.2013
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7
Calcium Uptake in Crude Tissue Preparation
Autor: Evangelia G. Kranias, Philip Bidwell
Publikováno v: P-Type ATPases ISBN: 9781493931781
The various isoforms of the sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) are responsible for the Ca(2+) uptake from the cytosol into the endoplasmic or sarcoplasmic reticulum (ER/SR). In some tissues, the activity of SERCA can be modulated by bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e854060c9e8989f889501b92ab743d
https://doi.org/10.1007/978-1-4939-3179-8_16
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8
c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells
Autor: H. Anne Leaver, Ayoola Bamisaiye, Gausal A. Khan, Maria Teresa Rizzo, Philip Bidwell, Stephen Rush
Publikováno v: Experimental Cell Research. 313:121-132
Hepatocyte growth factor (HGF) influences several components of the angiogenic response, including endothelial cell migration. While recent studies indicate a crucial role of HGF in brain angiogenesis, the signaling pathways that regulate brain endot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e655cbb6a8bd37503b2e08d32bf104
https://doi.org/10.1016/j.yexcr.2006.09.018
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10
Interaction of SERCA with the Transmembrane Domain of Phospholamban Measured by FRET in Live Cells
Autor: Philip Bidwell, Seth L. Robia
Publikováno v: Biophysical Journal. 102(3)
Phospholamban (PLB) is the key regulator of the SERCA calcium pump. Previous quantitative fluorescence resonance energy transfer (FRET) measurements between Cerulean-SERCA and YFP-PLB have shown that calcium and thapsigargin reduce the affinity of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37887d201f2d1e31244ca0d5a8d4236e
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