Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Philip Beineke"'
Autor:
Sheila K. Pierson, Laura Katz, Reece Williams, Melanie Mumau, Michael Gonzalez, Stacy Guzman, Ayelet Rubenstein, Ana B. Oromendia, Philip Beineke, Alexander Fosså, Frits van Rhee, David C. Fajgenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab. Authors here show that the c
Externí odkaz:
https://doaj.org/article/e0c518f68f5145bd81577393f7c19dec
Autor:
Valentin Hamy, Luis Garcia-Gancedo, Andrew Pollard, Anniek Myatt, Jingshu Liu, Andrew Howland, Philip Beineke, Emilia Quattrocchi, Rachel Williams, Michelle Crouthamel
Publikováno v:
Digital Biomarkers, Vol 4, Iss 1, Pp 26-44 (2020)
Background: Digital biomarkers that measure physical activity and mobility are of great interest in the assessment of chronic diseases such as rheumatoid arthritis, as it provides insights on patients’ quality of life that can be reliably compared
Externí odkaz:
https://doaj.org/article/c96c57ffb8684e57908ea9c95299e1f9
Autor:
Michael R Elashoff, Rachel Nuttall, Philip Beineke, Michael H Doctolero, Mark Dickson, Andrea M Johnson, Susan E Daniels, Steven Rosenberg, James A Wingrove
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40068 (2012)
BACKGROUND: Corus CAD is a clinically validated test based on age, sex, and expression levels of 23 genes in whole blood that provides a score (1-40 points) proportional to the likelihood of obstructive coronary disease. Clinical laboratory process v
Externí odkaz:
https://doaj.org/article/51ad6b202c0840ac97bb68ae555adcfd
Autor:
Rachel E. Williams, Andrew Howland, Andrew Pollard, Emilia Quattrocchi, Philip Beineke, Anniek Myatt, Luis Garcia-Gancedo, Valentin Hamy, Michelle Crouthamel, Jingshu Liu
Publikováno v:
Digital Biomarkers, Vol 4, Iss 1, Pp 26-44 (2020)
Digit Biomark
Digit Biomark
Background: Digital biomarkers that measure physical activity and mobility are of great interest in the assessment of chronic diseases such as rheumatoid arthritis, as it provides insights on patients’ quality of life that can be reliably compared
Autor:
Lisa Ensign, Peter Stokman, Peter G Stokman, Monika Mörsch, Dirk Langeneckhardt, Bradley Bitzer, Sami Boussetta, Valérie Cassan, Annemarie Voortman, Richard Kwock, Philip Beineke, Gernot Hochgräber, Sven Vogelgesang, Diego Herrera, Kristin Nuyens
Publikováno v:
Journal of the Society for Clinical Data Management. 1
INTRODUCTION: The essence of Risk-based Quality Management is to focus on what matters most. Sponsor companies are annually spending many billions of dollars on automated and manual data cleaning, utilizing internal and site resources to create the i
Autor:
Manjula Reddy, Sheila K Pierson, Craig Tendler, Alessia Dalla Pria, Alexander Fosså, Philip Beineke, Nancy A. Shadick, Mark Bower, Sushila A. Shenoy, Christopher S. Nabel, Alexander M. Gorzewski, Michael E. Weinblatt, Sophia A. T. Parente, Jason R. Ruth, Mary Guilfoyle, Laura M. Katz, Ana B Oromendia, Daniel J. Arenas, Taku Kambayashi, David M. Lee, Ruth-Anne Langan Pai, David C. Fajgenbaum, Frits van Rhee, Yasufumi Masaki, Jason G. Mezey
Publikováno v:
Blood Adv
Idiopathic multicentric Castleman disease (iMCD) is a poorly understood hematologic disorder involving cytokine-induced polyclonal lymphoproliferation, systemic inflammation, and potentially fatal multiorgan failure. Although the etiology of iMCD is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca99d86eae5f7a039e24dd4a68fab32
http://hdl.handle.net/10852/92185
http://hdl.handle.net/10852/92185
Autor:
Gregory S. Thomas, Brian Kent Rhees, Susan E. Daniels, Steven A. Rosenberg, Philip Beineke, William E. Kraus, John A. McPherson
Publikováno v:
Journal of Cardiovascular Translational Research
A gene expression score (GES) for obstructive coronary artery disease (CAD) has been validated in two multicenter studies. Receiver-operating characteristics (ROC) analysis of the GES on an expanded Personalized Risk Evaluation and Diagnosis in the C
Autor:
David C. Fajgenbaum, Philip Beineke, Jason R. Ruth, Manjula Reddy, Sheila K Pierson, Dustin Shilling, Laura M. Katz, Sofija Miljovska, Yasufumi Masaki, Jef Benbanaste, Alessia Dalla Pria, Michael E. Weinblatt, David M. Lee, Jason G. Mezey, Mark Bower, Mary Guilfoyle, Alexander Fosså, Christopher S. Nabel, Jeff Wiser, Frits van Rhee, Craig Tendler, Nancy A. Shadick, Ana B Oromendia, Sushila A. Shenoy
Publikováno v:
Blood. 132:3716-3716
Human herpesvirus-8(HHV-8)-negative/idiopathic multicentric Castleman disease (iMCD) is a rare and poorly understood disorder diagnosed in ~1,000 individuals in the USA each year. It involves polyclonal lymphoproliferation, constitutional symptoms, s
Autor:
Lin-Chi Chen, David S. Lee, Somnath Sarkar, Steven Blotner, Michael Elashoff, Mark Chandler, Ruthie Davi, Donald A. Berry, Philip Beineke
Publikováno v:
Journal of Clinical Oncology. 35:7021-7021
7021 Background: Clinical trials of experimental drugs require controls. Concurrently randomized controls are the gold standard for judging drug effect. Historical controls are not ideal but are much more efficient and economical. Historical controls
Autor:
Gary W. Witherell, Philip Beineke
Publikováno v:
Journal of Medical Virology. 63:8-16
Interferon (IFN) therapy (+/- ribavirin) is the only currently available treatment for chronic hepatitis C virus (HCV), but is not effective for a majority of patients. Several studies have correlated IFN response with substitutions in a small region