Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Philip Avner"'
Autor:
Andrea Cerase, Philip Avner
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100114- (2023)
The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with CHD8 mutations share common symptoms such as autistic behaviour, cognitive impairment, s
Externí odkaz:
https://doaj.org/article/ecaf1beaaa3045cc96c08091981cc9fa
Autor:
Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cel
Externí odkaz:
https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b
Autor:
Aurélia Guyochin, Sylvain Maenner, Erin Tsi-Jia Chu, Asma Hentati, Mikael Attia, Philip Avner, Philippe Clerc
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116109 (2014)
Random X-chromosome inactivation ensures dosage compensation in mammals through the transcriptional silencing of one of the two X chromosomes present in each female cell. Silencing is initiated in the differentiating epiblast of the mouse female embr
Externí odkaz:
https://doaj.org/article/3632c931d13f4fa19d431e19e9fd8b63
Autor:
Céline Morey, Philip Avner
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002212 (2011)
In humans, sexual dimorphism is associated with the presence of two X chromosomes in the female, whereas males possess only one X and a small and largely degenerate Y chromosome. How do men cope with having only a single X chromosome given that virtu
Externí odkaz:
https://doaj.org/article/9646eff3a0114dda842721d1b23d91f5
Autor:
Sylvain Maenner, Magali Blaud, Laetitia Fouillen, Anne Savoye, Virginie Marchand, Agnès Dubois, Sarah Sanglier-Cianférani, Alain Van Dorsselaer, Philippe Clerc, Philip Avner, Athanase Visvikis, Christiane Branlant
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000276 (2010)
In placental mammals, inactivation of one of the X chromosomes in female cells ensures sex chromosome dosage compensation. The 17 kb non-coding Xist RNA is crucial to this process and accumulates on the future inactive X chromosome. The most conserve
Externí odkaz:
https://doaj.org/article/215cd53525574e36a3ba442527d70a61
Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation.
Autor:
Constance Ciaudo, Agnès Bourdet, Michel Cohen-Tannoudji, Harry C Dietz, Claire Rougeulle, Philip Avner
Publikováno v:
PLoS Genetics, Vol 2, Iss 6, p e94 (2006)
A critical step in X-chromosome inactivation (XCI), which results in the dosage compensation of X-linked gene expression in mammals, is the coating of the presumptive inactive X chromosome by the large noncoding Xist RNA, which then leads to the recr
Externí odkaz:
https://doaj.org/article/2be574ea9f714efbaa4d57fea26ddf67
Autor:
Gian Gaetano Tartaglia, Mitchell Guttman, Alexandros Armaos, Philip Avner, Christoph Neumayer, Andrea Cerase
Publikováno v:
Nature Structural & Molecular Biology. 26:331-334
The long non-coding RNA Xist induces heterochromatinization of the X chromosome by recruiting repressive protein complexes to chromatin. Here we gather evidence, from the literature and from computational analyses, showing that Xist assemblies are si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6e915d3b8c3eac91e1798ecf0a0114
https://doi.org/10.1038/s41594-019-0223-0
https://doi.org/10.1038/s41594-019-0223-0
Autor:
Nerea Blanes Ruiz, Giuseppe Trigiante, Monica Di Giacomo, Alexander N. Young, Gabrielle M Sant, Sarah J. Marzi, Andrea Cerase, Andreas Buness, Andreas Hierholzer, Philip Avner, Manish Kumar, Michela Ascolani, Mirjam Arnold
Publikováno v:
Communications Biology
Communications Biology, 4 (1)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, 4 (1)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e3e18625767614e038f16d582be598
http://europepmc.org/articles/PMC8050208
http://europepmc.org/articles/PMC8050208
Xist long non-coding RNA induces heterochromatinization of the X-chromosome by accumulating in large ribonucleoprotein assemblies. We suggest that Xist regulates X chromosome inactivation by recruiting RNA-binding proteins via a mechanism of liquid-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200b17c5866ea2c31fcd47104105a450
Autor:
Andreas Buness, Mario Blanco, Andrea Cerase, Philip Avner, Mitchell Guttman, Davide Cirillo, Gian Gaetano Tartaglia, Alexandros Armaos
Long noncoding RNAs (lncRNAs, which comprise 68% of the human transcriptome with average length of 1,000 nt) interact with various RNA-binding proteins (RBPs) to mediate cellular functions1. Identification of lncRNA interactions through experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fed730e32f42eefa36cf34964383c4
https://resolver.caltech.edu/CaltechAUTHORS:20161026-132024065
https://resolver.caltech.edu/CaltechAUTHORS:20161026-132024065