Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity

Autor: Lalita Priyamvada, Philip Alabi, Andres Leon, Amrita Kumar, Suryaprakash Sambhara, Victoria A. Olson, Jason K. Sello, Panayampalli S. Satheshkumar

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Orthopoxviruses (OPXVs) are an increasing threat to human health due to the growing population of OPXV-naive individuals after the discontinuation of routine smallpox vaccination. Antiviral drugs that are effective as postexposure treatments against

Externí odkaz: https://doaj.org/article/5e5ed15cf26846bfa2b70b2f2ca759ae

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

Autor: Giovanna Gomez d'Ayala, Evan Craig, Jason K. Sello, Philip Alabi, Anna Calarco, Peter E. Kima, Raffaele Conte, Pierfrancesco Cerruti, Veronica Ambrogi

Publikováno v: Frontiers in cellular and infection microbiology 11 (2021). doi:10.3389/fcimb.2021.702676
info:cnr-pdr/source/autori:Craig, Evan; Calarco, Anna; Conte, Raffaele; Ambrogi, Veronica; d'Ayala, Giovanna Gomez; Alabi, Philip; Sello, Jason K.; Cerruti, Pierfrancesco; Kima, Peter E./titolo:Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections/doi:10.3389%2Ffcimb.2021.702676/rivista:Frontiers in cellular and infection microbiology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Frontiers in Cellular and Infection Microbiology

Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660105234436263569817f7968235c38
https://doi.org/10.3389/fcimb.2021.702676

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

Autor: Adam Lavertu, Nicholas R. Weir, Amanda Dombroski, Amy Li, Nicole J. Polyakov, David Yao, Vladimir Denic, Jing Zhou, Charlene Chan, Gaelen T. Hess, David W. Morgens, Kyuho Han, Andrew J Kane, Jason K. Sello, C. Kimberly Tsui, Michael M. Dubreuil, Russ B. Altman, Philip Alabi, Emma L. Handy, Michael C. Bassik

Publikováno v: eLife, Vol 8 (2019)
eLife

The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82cafeb61e78e78bd0b38dc89ac72c6
https://doi.org/10.7554/elife.48434