A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

Autor: Hung Ping Shih, Philip A. Seymour, Nisha A. Patel, Ruiyu Xie, Allen Wang, Patrick P. Liu, Gene W. Yeo, Mark A. Magnuson, Maike Sander

Publikováno v: Cell Reports, Vol 13, Iss 2, Pp 326-336 (2015)

The generation of pancreas, liver, and intestine from a common pool of progenitors in the foregut endoderm requires the establishment of organ boundaries. How dorsal foregut progenitors activate pancreatic genes and evade the intestinal lineage choic

Externí odkaz: https://doaj.org/article/2f846faee2cb467b9d1d7453dc06e4f4

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Autor: Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.

Externí odkaz: https://doaj.org/article/a2eaa62cc36b47aea2401f79983fdc5d

Canonical notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Autor: Alison Farley, Freddy Radtke, Dong Liu, C. Clare Blackburn, Philip A. Seymour, Svetlana Ulyanchenko, Anastasia I. Kousa, Palle Serup, Martyna Popis, François Guillemot, Simon R. Tomlinson, Mette C. Jørgensen, Paul Rouse, Kathy E. O'Neill, Ute Koch

Publikováno v: Liu, D, Kousa, A, O'Neill, K, Rouse, P, Popis, M, Farley, A, Tomlinson, S, Ulyanchenko, S, Guillemot, F, Seymour, P A, Jorgensen, M, Serup, P, Koch, U, Radtke, F & Blackburn, C 2020, ' Canonical notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development ', Development . https://doi.org/10.1242/dev.178582
Development (Cambridge, England)
article-version (VoR) Version of Record
Liu, D, Kousa, A I, O'Neill, K E, Rouse, P, Popis, M, Farley, A M, Tomlinson, S R, Ulyanchenko, S, Guillemot, F, Seymour, P A, Jørgensen, M C, Serup, P, Koch, U, Radtke, F & Blackburn, C C 2020, ' Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development ', Development (Cambridge, England), vol. 147, dev178582, pp. 1-16 . https://doi.org/10.1242/dev.178582

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f59d4dfb94740ee3b061dd4b902fd68
https://www.pure.ed.ac.uk/ws/files/153893900/dev178582.full.pdf

Canonical NOTCH signaling controls the early progenitor state and emergence of the medullary epithelial lineage in fetal thymus development

Autor: Freddy Radtke, Popis M, Kousa Ai, Farley Am, O’Neill Ke, Liu D, Guillemot F, Tomlinson, Ute Koch, Svetlana Ulyanchenko, Philip A. Seymour, C. Clare Blackburn, Palle Serup

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d93fcfc741254c66c0ef18f74cb6c9

Inhibition of Cdk5 Promotes β-cell Differentiation from Ductal Progenitors

Autor: Gunter Leuckx, Charlotte L. Mattsson, Olov Andersson, Palle Serup, Yannick Verdonck, Daisuke Sakano, Philip A. Seymour, Shoen Kume, Harry Heimberg, Ka-Cheuk Liu, Linn Rautio, Willem Staels

Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2,200 small molecules in zebrafish, we identified an inhibitor of Cdk5 (roscovitine), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad66abacc528e8ffc36c37c6428c4f22
https://hdl.handle.net/20.500.14017/5b5273b5-2425-471d-9bde-51524e0f5e0a