Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Philip A. Searle"'
Publikováno v:
SLAS Technology. 26:113-116
Centralized high-throughput purification laboratories routinely produce large numbers of test tubes with fractions containing the purified compounds of interest interspersed with test tubes containing fractions collected from undesired peaks. Because
Publikováno v:
Reaction Chemistry & Engineering. 4:1589-1594
A detailed overview of a newly developed method for the analysis and processing of chemical library screens is reported. Integration of a DESI 2D source in a pharmaceutical drug discovery setting is accomplished by utilizing this platform on multiple
Autor:
Jasmina Marjanovic, Stevan W. Djuric, Noah P. Tu, Aleksandra Baranczak, Philip A. Searle, Anil Vasudevan
Publikováno v:
ACS Medicinal Chemistry Letters. 8:461-465
The productivity of medicinal chemistry programs can be significantly increased through the introduction of automation, leading to shortened discovery cycle times. Herein, we describe a platform that consolidates synthesis, purification, quantitation
Autor:
Noah P. Tu, Stevan W. Djuric, Philip A. Searle, Jeffrey Y. Pan, J. David Sutherland, Thomas A. Nemcek, Jill E. Hochlowski
Publikováno v:
SLAS Technology. 19:176-182
A flexible and integrated flow-chemistry-synthesis-purification compound-generation and sample-management platform has been developed to accelerate the production of small-molecule organic-compound drug candidates in pharmaceutical research. Central
Autor:
Jill E. Hochlowski, Philip A. Searle, Stephen G. Spanton, Noah P. Tu, Jeffrey Y. Pan, Stevan W. Djuric
Publikováno v:
Journal of Flow Chemistry. 1:56-61
We report herein a high-throughput integrated ynthesis–purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmen
Publikováno v:
Journal of Chromatography A. 1216:6162-6169
Experiments were performed to demonstrate the potential of counter-current chromatography (CCC) for the isolation of drugs and their metabolites from biological matrices relevant to the metabolism studies of pharmaceutical research. Examples of typic
Publikováno v:
Journal of Chromatography A. 1216:4154-4160
Experiments were performed to evaluate whether counter-current chromatography (CCC) could function as an alternative purification method to reversed-phase high-performance liquid chromatography (RP-HPLC) and normal-phase supercritical fluid chromatog
Publikováno v:
Journal of laboratory automation. 21(3)
A novel methodology for the synthesis and purification of drug-like compound libraries has been developed through the use of a microwave reactor with an integrated high-performance liquid chromatography-mass spectrometry (HPLC-MS) system. The strateg