Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

Autor: Philip A. S. Lowden, Sunny Sunshine, Kim Holt, Hilary Moffitt, Donna L. Moolman, Amy L. Barker, Gillian P. Bates, Kirupa Sathasivam, Benjamin Woodman, Adrian Peter Revington, Jean-Luc Beunard, Emma Hockly, Jamie Tse, Erich E. Wanker

Publikováno v: Neurobiology of Disease, Vol 21, Iss 1, Pp 228-236 (2006)

Huntington's disease (HD) is an inherited progressive neurological disorder for which there is no effective therapy. It is caused by a CAG/polyglutamine repeat expansion that leads to abnormal protein aggregation and deposition in the brain. Several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a34319420c19c1e82d20e24506c213
http://www.sciencedirect.com/science/article/pii/S0969996105002056

Minocycline and doxycycline are not beneficial in a model of Huntington's disease

Autor: Gillian P. Bates, Shabnam Ghazi-Noori, Donna L. Smith, Kirupa Sathasivam, Philip A. S. Lowden, Benjamin Woodman, Emma Hockly, Amarbirpal Mahal

Publikováno v: Annals of Neurology. 54:186-196

Huntington's Disease (HD) is an inherited neurological disorder causing movement impairment, personality changes, dementia, and premature death, for which there is currently no effective therapy. The modified tetracycline antibiotic, minocycline, has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85605f68255d88d58d610b9ae1e2b85f
https://doi.org/10.1002/ana.10614

Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

Autor: Joseph S. Vyle, Philip A. S. Lowden, Nina Moran, Dario M. Bassani, Jean-Pierre Desvergne, James H. R. Tucker, Sonja Keiper

Publikováno v: Moran, N, Bassani, D M, Desvergne, J-P, Keiper, S, Lowden, P A S, Vyle, J & Tucker, J H R 2006, ' Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe ' Chemical Communications, vol. 2006, no. 48, pp. 5003-5005 . DOI: 10.1039/b611650g

A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d49060df2ce2ebe27aa780749b1ef7
https://pubmed.ncbi.nlm.nih.gov/17146508

The Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Autor: Günter A. Böhm, Peter F. Leadlay, James Staunton, Philip A. S. Lowden

Publikováno v: Angewandte Chemie International Edition in English. 35:2249-2251

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9310f0a52e9d07cedfa104321616bd18
https://doi.org/10.1002/anie.199622491

The First Biosynthetic Studies of the Azinomycins: Acetate Incorporation into Azinomycin B

Autor: Christophe Corre, Philip A. S. Lowden

Publikováno v: ChemInform. 35

13 C-Labelled acetate efficiently labels the antitumour natural product azinomycin B, revealing a polyketide origin for the naphthoate fragment, that threonine is the probable precursor of the enol fragment, and that α-ketoglutarate is a probable pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be5780d84972a642bd9ffb077d49b64
https://doi.org/10.1002/chin.200435224