Data from PROgesterone Therapy for Endometrial Cancer Prevention in Obese Women (PROTEC) Trial: A Feasibility Study

Autor: Emma J. Crosbie, Henry C. Kitchener, Richard J. Edmondson, Michelle L. MacKintosh, Michelle Needham, Philip W. Pemberton, Joseph Shaw, James Bolton, Bhavna Lakhiani, Matthew Gittins, Jennifer L. Allen, Abigail E. Derbyshire

Obesity is the major etiologic driver for endometrial cancer. The levonorgestrel intrauterine system (LNG-IUS) reduces the risk of endometrial cancer and its precursor, atypical hyperplasia. We assessed feasibility and uptake of the LNG-IUS for prima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2513ab71dfeb49247210a1551292efd
https://doi.org/10.1158/1940-6207.c.6546986.v1

Supplementary Data from PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial

Autor: Emma J. Crosbie, Henry C. Kitchener, W. David Ryder, Joseph Shaw, Philip W. Pemberton, Richard J. Slade, Rahamatulla Latheef, Kyle Gilmour, Sean Burns, Saad Ali, Jennifer L. Allen, Vanitha N. Sivalingam, Zoe Maskell, Sarah J. Kitson

Supplementary methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedb79883eeb151c50db31289da530e
https://doi.org/10.1158/1078-0432.22471364

Accuracy and precision analysis for a biophotonic assay of C-reactive protein

Autor: Oliver J Hedaux, Chris Hyde, Rouslan V. Olkhov, Philip James-Pemberton, Andrew M. Shaw, Urszula Łapińska, Mark Helliwell

Publikováno v: The Analyst. 145:2751-2757

A multiplexed biophotonic assay platform has been developed using the localised particle plasmon in gold nanoparticles assembled in an array and functionalised for two assays: total IgG and C-reactive protein (CRP). A protein A/G (PAG) assay, calibra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5152a116acd44dc3962741171323550e
https://doi.org/10.1039/c9an02516b

Baseline serum HE4 but not tissue HE4 expression predicts response to the levonorgestrel-releasing intrauterine system in atypical hyperplasia and early stage endometrial cancer

Autor: Y Louise Wan, Roya Behrouzi, Chloe E Barr, Emma J Crosbie, Rhona J McVey, Zoe Maskell, Neil A J Ryan, Katie Stocking, James Bolton, Abigail E. Derbyshire, Philip W. Pemberton

Publikováno v: Behrouzi, R, Ryan, N, Barr, C, Derbyshire, A, Wan, L, Maskell, Z, Stocking, K, Pemberton, P, Bolton, J, McVey, R J & Crosbie, E 2020, ' Baseline serum HE4 but not tissue HE4 expression predicts response to the levonorgestrel-releasing intrauterine system in atypical hyperplasia and early stage endometrial cancer ', Cancers . https://doi.org/10.3390/cancers12020276
Cancers
Behrouzi, R, Ryan, N A J, Barr, C E, Derbyshire, A E, Wan, Y L, Maskell, Z, Stocking, K, Pemberton, P W, Bolton, J, McVey, R J & Crosbie, E J 2020, ' Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer ', Cancers, vol. 12, no. 2 . https://doi.org/10.3390/cancers12020276
Cancers, Vol 12, Iss 2, p 276 (2020)
Volume 12
Issue 2

The levonorgestrel-releasing intrauterine system (LNG-IUS) is a conservative management option for atypical hyperplasia (AH) and low grade early stage endometrial cancer (EEC), but around 1 in 3 patients fail to respond to treatment. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7369e016706a52ad14911956f2ea52b2
https://doi.org/10.3390/cancers12020276

The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk

Autor: Babur Ahmed, Rhona J McVey, Emma J Crosbie, Martyna Kamieniorz, Catherine L. Higgins, Abigail E. Derbyshire, Basil J. Ammori, Akheel A. Syed, Andrew G Renehan, Philip W. Pemberton, Michelle L. MacKintosh, James Bolton, Henry C Kitchener, Mahshid Nickkho-Amiry, Bilal H. Kirmani

Publikováno v: Mackintosh, M, Derbyshire, A, McVey, R, Bolton, J, Nickkho-Amiry, M, Higgins, C L, Kamieniorz, M, Pemberton, P W, Kirmani, B H, Ahmed, B, Syed, A, Ammori, B, Renehan, A, Kitchener, H & Crosbie, E 2019, ' The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk ', International Journal of Cancer, vol. 144, no. 3, pp. 641-650 . https://doi.org/10.1002/ijc.31913
International Journal of Cancer

Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening and prevention strategies, we assessed the impact of obesity and subsequent bariatric surgery‐induced weight loss on endometrial morphology and molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63088df8a68af9055966e6615d2e2f4
https://doi.org/10.1002/ijc.31913