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pro vyhledávání: '"Philip A. Keene"'
Publikováno v:
Journal of Chemical Technology & Biotechnology. 82:1099-1106
BACKGROUND: Pharmaceutical companies continue to evaluate β-amino acids and β-lactams in a range of drug candidates. The development of a highly efficient and selective bioresolution of cyclic β-lactam substrates could yield enantiopure lactams an
Autor:
Philip Alexander Keene, Karen E. Holt, Richard C. Lloyd, Raymond McCague, Michael C. Lloyd, Mark E. B. Smith, Jonathan P. Swift, Stephen Taylor
Publikováno v:
Tetrahedron. 60:717-728
The synthesis of several cyclic amino acids that have all the necessary structural features to make them ideal scaffolds for use in medicinal chemistry is described. A key step in each synthesis is the use of hydrolase enzymes to define a chiral cent
Autor:
Geert M. van der Kraan, Bei Yin, Philip A. Keene, Malcolm James, Terry M. Williams, Donald J. Love, Otto P. van Ruiten
Publikováno v:
All Days.
Worldwide, the production of natural gas and now oil from shale basins (source rock) has been embraced as a commercially viable way of producing unconventional energy resources leading to a revolution in gas production in the US. Developments to inve