Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Philip A. Efron"'
Autor:
Lauren S. Kelly, Jennifer A. Munley, Erick E. Pons, Kolenkode B. Kannan, Elizabeth M. Whitley, Letitia E. Bible, Philip A. Efron, Alicia M. Mohr
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 3, Pp 367-376 (2024)
Abstract Background Severe trauma is associated with systemic inflammation and organ dysfunction. Preclinical rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human trauma. The aim
Externí odkaz:
https://doaj.org/article/89b941a61a2944e1adf0e4f2fda1475d
Autor:
Adam D. Price, Ellen R. Becker, Evan L. Barrios, Monty B. Mazer, Patrick W. McGonagill, Christian B. Bergmann, Michael D. Goodman, Robert W. Gould, Mahil Rao, Valerie E. Polcz, Tamara A. Kucaba, Andrew H. Walton, Sydney Miles, Julie Xu, Muxuan Liang, Tyler J. Loftus, Philip A. Efron, Kenneth E. Remy, Scott C. Brakenridge, Vladimir P. Badovinac, Thomas S. Griffith, Lyle L. Moldawer, Richard S. Hotchkiss, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that
Externí odkaz:
https://doaj.org/article/0d40c4cf70d04695a92503d2f0ae310b
Autor:
Franccesco P. Boeno, PhD, Luiz Fernando W. Roesch, PhD, Philip A. Efron, MD, Orlando Laitano, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 8, p e1144 (2024)
CONTEXT:. Sepsis leads to multiple organ dysfunction and negatively impacts patient outcomes. Skeletal muscle disuse is a significant comorbidity in septic patients during their ICU stay due to prolonged immobilization. HYPOTHESIS:. Combination of se
Externí odkaz:
https://doaj.org/article/57135bb2f5cb4c758971ab7e49f3a7f7
Autor:
Victoria J. Nolan, PhD, Jeremy A. Balch, MD, Naveen P. Baskaran, MD, MSHI, Benjamin Shickel, PhD, Philip A. Efron, MD, FACS, FCCM, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD, MS, FCCM, FASN, Christopher J. Tignanelli, MD, MS, FACS, FAMIA, Ray E. Moseley, PhD, Tyler J. Loftus, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 8, p e1131 (2024)
Background:. Surrogates, proxies, and clinicians making shared treatment decisions for patients who have lost decision-making capacity often fail to honor patients’ wishes, due to stress, time pressures, misunderstanding patient values, and project
Externí odkaz:
https://doaj.org/article/9e3b4ebc849f49cab85d6c5ecca4514e
Autor:
Tyler J. Loftus, Jeremy A. Balch, Kenneth L. Abbott, Die Hu, Matthew M. Ruppert, Benjamin Shickel, Tezcan Ozrazgat-Baslanti, Philip A. Efron, Patrick J. Tighe, William R. Hogan, Parisa Rashidi, Michelle I. Cardel, Gilbert R. Upchurch, Azra Bihorac
Publikováno v:
PLOS Digital Health, Vol 3, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/68cd616bf87a42399ad46858a375755d
Autor:
Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD
Publikováno v:
Annals of Surgery Open, Vol 5, Iss 2, p e429 (2024)
Objective:. To determine whether certain patients are vulnerable to errant triage decisions immediately after major surgery and whether there are unique sociodemographic phenotypes within overtriaged and undertriaged cohorts. Background:. In a fair s
Externí odkaz:
https://doaj.org/article/d61e92eec95a4e538b624f9469e1d686
Autor:
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who devel
Externí odkaz:
https://doaj.org/article/c3d9f1e91fd841aa9fdb8d5f4c7a4bf1
Autor:
Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney, Lyle L. Moldawer
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admit
Externí odkaz:
https://doaj.org/article/ebd16a5d714d405c8c683d468eb7bc5b
Autor:
Jeremy A. Balch, Tyler J. Loftus, Philip A. Efron, Alicia M. Mohr, Gilbert R. Upchurch, R. Stephen Smith
Publikováno v:
World Journal of Emergency Surgery, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background Outcomes following aortic occlusion for trauma and hemorrhagic shock are poor, leading some to question the clinical utility of aortic occlusion in this setting. This study evaluates neurologically intact survival following resusc
Externí odkaz:
https://doaj.org/article/cad3cd92bb2144168e4920a326f4897e
Autor:
Molly Q. Nyren, Amanda C. Filiberto, Patrick W. Underwood, Kenneth L. Abbott, Jeremy A. Balch, Francesca Dal Mas, Lorenzo Cobianchi, Philip A. Efron, Brian C. George, Benjamin Shickel, Gilbert R. Upchurch, George A. Sarosi, Tyler J. Loftus
Publikováno v:
World Journal of Emergency Surgery, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Background Common bile duct exploration (CBDE) is safe and effective for managing choledocholithiasis, but most US general surgeons have limited experience with CBDE and are uncomfortable performing this procedure in practice. Surgical train
Externí odkaz:
https://doaj.org/article/3b89c155a2334311b874ec43e11e6b78