Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Philip A. Chambers"'
Autor:
Laura Smith, Euan W Baxter, Philip A Chambers, Caroline A Green, Andrew M Hanby, Thomas A Hughes, Claire E Nash, Rebecca A Millican-Slater, Lucy F Stead, Eldo T Verghese, Valerie Speirs
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139698 (2015)
MicroRNA (miR) expression is commonly dysregulated in many cancers, including breast. MiR-92 is one of six miRs encoded by the miR-17-92 cluster, one of the best-characterised oncogenic miR clusters. We examined expression of miR-92 in the breast epi
Externí odkaz:
https://doaj.org/article/4f8c107e3ba34a2abba7803a3bd0afe1
Autor:
Margaret A. Knowles, Claire Taylor, H Snowden, J M Askham, Fiona M. Platt, Philip A. Chambers
Publikováno v:
Oncogene. 29:150-155
The phosphatidylinositol-3-kinase (PI3 kinase)-AKT pathway is frequently activated in cancer. Recent reports have identified a transforming mutation of AKT1 in breast, colorectal, ovarian and lung cancers. We report here the occurrence of this mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c898f1a7808c13668266f5308305ac
https://doi.org/10.1038/onc.2009.315
https://doi.org/10.1038/onc.2009.315
Autor:
Philip A. Chambers, Suzanne A. Eccles, Carol Box, Christopher M. Nutting, Paul Workman, Kevin J. Harrington, Susanne J. Rogers, Peter Rhŷs-Evans, Yolanda Barbachano
Publikováno v:
The Journal of Pathology. 218:122-130
Dramatic responses to epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitors may be seen in non-small cell lung cancers (NSCLCs) with a sensitizing mutation of the EGFR TK domain. It is not known how to predict response in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::688070df896d92c67685b5a36af5ca18
https://doi.org/10.1002/path.2515
https://doi.org/10.1002/path.2515
Autor:
Charlotte M. Proby, Peter Karran, Peter O'Donovan, C. M. Perrett, N. R. Attard, Catherine A. Harwood, Philip A. Chambers, Jane M. McGregor
Publikováno v:
British Journal of Cancer
The immunosuppressant azathioprine is used to prevent graft rejection after organ transplantation. To investigate whether azathioprine-associated mutagenesis contributes to the high incidence of skin tumours in organ transplant recipients (OTRs), we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d420bd0c3f485b24afcd02be2425d8d
http://europepmc.org/articles/PMC2570526
http://europepmc.org/articles/PMC2570526
Autor:
Carolyn D. Hurst, Emma J. Chapman, Joanne S. Aveyard, Eva Pitt, Philip A. Chambers, Margaret A. Knowles
Publikováno v:
Oncogene. 25:5037-5045
The CDKN2A locus is frequently inactivated in urothelial cell carcinoma (UCC), yet how this alteration contributes to bladder tumorigenesis is not known. Although most UCC express telomerase, inactivation of the p16/Rb pathway is generally required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17645a0ca5df4609552df705192a052
https://doi.org/10.1038/sj.onc.1209513
https://doi.org/10.1038/sj.onc.1209513
Publikováno v:
Clinical Cancer Research. 11:5740-5747
Purpose: There are significant differences in reported frequencies, modes of inactivation, and clinical significance of CDKN2A in urothelial cell carcinoma (UCC). We aimed to address these issues by investigating all possible modes of inactivation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa41d5bda6cd6c777920e6aa56fe784
https://doi.org/10.1158/1078-0432.ccr-05-0411
https://doi.org/10.1158/1078-0432.ccr-05-0411
Autor:
Claire Taylor, Margaret A. Tucker, Philip A. Chambers, D. Timothy Bishop, Mark Harland, Jeanet A.C. ter Huurne, Kairen Kukalizch, Nelleke A. Gruis, Julia A. Newton Bishop, Alisa M. Goldstein, Juliette Randerson-Moor, Femke A. de Snoo
Publikováno v:
Oncogene. 24:4604-4608
Germline mutations of CDKN2A that affect the p16INK4a transcript have been identified in numerous melanoma pedigrees worldwide. In the UK, over 50% of pedigrees with three or more cases of melanoma have been found to carry mutations of CDKN2A. Mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c6834fd08798cf6da2c9828a4e98dc
https://doi.org/10.1038/sj.onc.1208678
https://doi.org/10.1038/sj.onc.1208678
Autor:
Faye Turner, Samantha Beswick, D. Timothy Bishop, Julia A. Newton Bishop, Claire Taylor, Anthony J. Swerdlow, Isabel dos Santos Silva, Mark Harland, Sharon Jackson, Juliette Randerson-Moor, Philip A. Chambers
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 14:913-918
Somatic mutations of BRAF have been identified in both melanoma tumors and benign nevi. Germ line mutations in BRAF have not been identified as causal in families predisposed to melanoma. However, a recent study suggested that a BRAF haplotype was as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35bededab2f07c4793eb84add5bec0e
https://doi.org/10.1158/1055-9965.epi-04-0568
https://doi.org/10.1158/1055-9965.epi-04-0568
Publikováno v:
British Journal of Nutrition. 89:159-166
The polymerase chain reaction (PCR) technique was used to investigate the fate of a transgene in the rumen of sheep fed silage and maize grains from an insect-resistant maize line. A 1914-bp DNA fragment containing the entire coding region of the syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0767e6f462451147b53cfa594d599fa7
https://doi.org/10.1079/bjn2002764
https://doi.org/10.1079/bjn2002764
Publikováno v:
Journal of Antimicrobial Chemotherapy. 49:161-164
We have examined the fate of an antibiotic resistance marker, incorporated into transgenic maize when fed to chicks. Plant-derived markers were found in the crops of five birds fed transgenic maize and in the stomach contents of two birds. The plant-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978201aa2a7adaea6d3e2ee3ed6b1b24
https://doi.org/10.1093/jac/49.1.161
https://doi.org/10.1093/jac/49.1.161