Výsledky vyhledávání - "Philip A Stumbles"

Akademický článek

Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM‐85

Autor: Jean‐Francois Lauzon‐Joset, Kyle T Mincham, Naomi M Scott, Yasmine Khandan, Philip A Stumbles, Patrick G Holt, Deborah H Strickland

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)

Abstract Objectives Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the

Externí odkaz: https://doaj.org/article/fa8d03d0ce44418eb1c52a7fbc1a765a

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Akademický článek

Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.

Autor: Deborah H Strickland, Vanessa Fear, Seth Shenton, Mathew E Wikstrom, Graeme Zosky, Alexander N Larcombe, Patrick G Holt, Cassandra Berry, Christophe von Garnier, Philip A Stumbles

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111520 (2014)

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung microenvironments in order to regulate tolerance or immunity to inhaled antigens and pathogens. Inf

Externí odkaz: https://doaj.org/article/f17144c51000490d845fae03dbea93a1

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Akademický článek

Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.

Autor: Catherine Rinaldi, William J Penhale, Philip A Stumbles, Guan Tay, Cassandra M Berry

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89674 (2014)

In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to p

Externí odkaz: https://doaj.org/article/1eeeb4e8804a4ea48cfef369b256d9f7

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Stimulation of alpha-1 adrenoceptors may intensify cutaneous inflammation in complex regional pain syndrome

Autor: Linda K. Wijaya, Michael V. Morici, Philip A. Stumbles, Philip M. Finch, Peter D. Drummond

Publikováno v: Pain.

Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup of patients with complex regional pain syndrome (CRPS). Activating α 1 -adrenoceptors in epidermal cells increases production of the proinflammatory cytokine interleukin-6 (IL-6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b73acc0200fc6b5e1b0c88506b6651
https://pubmed.ncbi.nlm.nih.gov/35994594

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Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

Autor: Alexander N. Larcombe, Thomas Iosifidis, Rachel E. Foong, Luke J. Berry, Philip A. Stumbles, Deborah H. Strickland, Peter D. Sly, Anthony Kicic

Publikováno v: Respiratory physiologyneurobiology. 298

A significant proportion of chronic obstructive pulmonary disease exacerbations are strongly associated with rhinovirus infection (HRV). In this study, we combined long-term cigarette smoke exposure with HRV infection in a mouse model. Our aim was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd6c83c6885bbb6f8ce2998cbfe1900
https://pubmed.ncbi.nlm.nih.gov/35063696

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Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

Autor: Deborah H. Strickland, Philip A. Stumbles, Jean Francois Lauzon-Joset, Patrick G. Holt, Kyle T Mincham, Yasmine Khandan, Naomi M. Scott

Publikováno v: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)

Objectives Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91f762dc168cac6e9ca46f4a335666f
https://pubmed.ncbi.nlm.nih.gov/34249358

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Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

Autor: Patrick G. Holt, Deborah H. Strickland, Yasmine Khandan, Jean Francois Lauzon-Joset, Naomi M. Scott, Kyle T Mincham, Philip A. Stumbles

ObjectivesIncomplete maturation of immune regulatory functions at birth are antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the benign m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::088e1d3e747b905326f832b42073bd0c
https://doi.org/10.1101/2021.03.02.433517

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Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming

Autor: Jean Francois Lauzon-Joset, Naomi M. Scott, Anya C. Jones, Marie Bodinier, Kyle T Mincham, Deborah H. Strickland, Patrick G. Holt, Philip A. Stumbles, Anthony Bosco

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, 11, pp.601494. ⟨10.3389/fimmu.2020.601494⟩
Frontiers in Immunology, Vol 11 (2020)

International audience; We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a00ed74816f2205bcb083fd0a1efc3e
https://doi.org/10.3389/fimmu.2020.601494

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