Výsledky vyhledávání - "Philip A Mudd"

Akademický článek

Assessment of antibodies in the upper and lower human respiratory tract at steady state and after respiratory viral infection

Autor: Marios Koutsakos, Jackson S Turner, M Cristina Vazquez Guillamet, Daniel Reynolds, Tingting Lei, Derek E Byers, Ali H Ellebedy, Philip A Mudd

Publikováno v: Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)

Abstract Objectives There is an increasing appreciation for the need to study mucosal antibody responses in humans. Our aim was to determine the utility of different types of samples from the human respiratory tract, specifically nasopharyngeal (NP)

Externí odkaz: https://doaj.org/article/0889cf52f04a40f68c7ee341b9a9fdcb

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Akademický článek

Acute phase CD8+ T lymphocytes against alternate reading frame epitopes select for rapid viral escape during SIV infection.

Autor: Andrew D Walsh, Benjamin N Bimber, Arpita Das, Shari M Piaskowski, Eva G Rakasz, Alexander T Bean, Philip A Mudd, Adam J Ericsen, Nancy A Wilson, Austin L Hughes, David H O'Connor, Nicholas J Maness

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61383 (2013)

CD8+ T Lymphocytes (CTL) can control AIDS virus replication. However, natural selection favoring viral variants that escape CTL recognition is a common feature of both simian immunodeficiency virus (SIV) infection of macaques and HIV infection of hum

Externí odkaz: https://doaj.org/article/f18a8660973e4cda8f75ad50e5bbd410

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Akademický článek

Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples

Autor: Thomas Liechti, Yaser Iftikhar, Massimo Mangino, Margaret Beddall, Charles W. Goss, Jane A. O’Halloran, Philip A. Mudd, Mario Roederer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

The association of specific immune cell types with SARS-CoV-2 severity is not fully understood. Here the authors analyse PBMC from individuals recovered from COVID-19 and propose immune cell signatures post recovery that are associated with disease s

Externí odkaz: https://doaj.org/article/4332ecc498cb426a98bc215965288a51

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Akademický článek

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

Publikováno v: International Journal of Infectious Diseases, Vol 103, Iss , Pp 25-32 (2021)

Objective: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigat

Externí odkaz: https://doaj.org/article/aa64df75735341c59242e660d8c57951

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Akademický článek

Interleukin-6 Trajectory and Secondary Infections in Mechanically Ventilated Patients With Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Treated With Interleukin-6 Receptor Blocker

Autor: M. Cristina Vazquez Guillamet, MD, Hrishikesh S. Kulkarni, MD, MSCI, Kevin Montes, MD, Maanasi Samant, MD, Preet A. Shaikh, MD, Kevin Betthauser, PharmD, Philip A. Mudd, MD, PhD, Daniel Reynolds, MD, Jane O’Halloran, MD, PhD, Patrick Lyons, MD, Colleen McEvoy, MD, Rodrigo Vazquez Guillamet, MD

Publikováno v: Critical Care Explorations, Vol 3, Iss 2, p e0343 (2021)

Objectives:. To describe the infectious complications and interleukin-6 trajectories in mechanically ventilated patients with coronavirus disease 2019. Design:. Retrospective cohort study. Setting:. ICUs at Washington University-Barnes Jewish Hospita

Externí odkaz: https://doaj.org/article/55e0430d02af4a568875531c9f546c26

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Akademický článek

Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

Publikováno v: JCI Insight, Vol 6, Iss 4 (2021)

Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.Me

Externí odkaz: https://doaj.org/article/18f9da8346e44ec09eb8792466de3b9a

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Akademický článek

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

Publikováno v: JCI Insight, Vol 5, Iss 17 (2021)

COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained vira

Externí odkaz: https://doaj.org/article/e8dd85cce0b24e16aeb05e045c745304

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Akademický článek

SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response

Autor: Jackson S. Turner, Aaron Day, Wafaa B. Alsoussi, Zhuoming Liu, Jane A. O’Halloran, Rachel M. Presti, Bruce K. Patterson, Sean P. J. Whelan, Ali H. Ellebedy, Philip A. Mudd

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive

Externí odkaz: https://doaj.org/article/726c86b25c71472686c5fd888af25739

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