Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Philip A Gruppuso"'
Autor:
Juanita K Hodax, Jose Bernardo Quintos, Philip A Gruppuso, Qian Chen, Salomi Desai, Chathuraka T Jayasuriya
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218399 (2019)
Aggrecan is an integral component of the extracellular matrix in cartilaginous tissues, including the growth plate. Heterozygous defects in the aggrecan gene have been identified as a cause of autosomal dominant short stature, bone age acceleration,
Externí odkaz:
https://doaj.org/article/2b0e7354271d45abb5cfad1087ca862c
Autor:
Valerie Zabala, Joan M Boylan, Paul Thevenot, Anderson Frank, Dewahar Senthoor, Varun Iyengar, Hannah Kim, Ari Cohen, Philip A Gruppuso, Jennifer A Sanders
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227038 (2019)
There are few effective targeted strategies to reduce hepatic ischemia-reperfusion (IR) injury, a contributor to poor outcomes in liver transplantation recipients. It has been proposed that IR injury is driven by the generation of reactive oxygen spe
Externí odkaz:
https://doaj.org/article/12b5b00b6c6e468d98366405ff82160d
Autor:
Philip A Gruppuso, Joan M Boylan, Valerie Zabala, Nicola Neretti, Nebiyu A Abshiru, Jacek W Sikora, Emma H Doud, Jeannie M Camarillo, Paul M Thomas, Neil L Kelleher, Jennifer A Sanders
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203351 (2018)
Chromatin structure, a key contributor to the regulation of gene expression, is modulated by a broad array of histone post-translational modifications (PTMs). Taken together, these "histone marks" comprise what is often referred to as the "histone co
Externí odkaz:
https://doaj.org/article/1caaee12c994468fb5449398614069e4
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21729 (2011)
Our understanding of signal transduction networks in the physiological context of an organism remains limited, partly due to the technical challenge of identifying serine/threonine phosphorylated peptides from complex tissue samples. In the present s
Externí odkaz:
https://doaj.org/article/3cd6ac30a04b436da7dfe331769df240
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29513 (2011)
Resveratrol is a plant-derived polyphenol that extends lifespan and healthspan in model organism. Despite extensive investigation, the biological processes mediating resveratrol's effects have yet to be elucidated. Because repression of translation s
Externí odkaz:
https://doaj.org/article/d15ed6546ef9423292283815e57dc1c6
Autor:
Rosa H Jimenez, Ju-Seog Lee, Mirko Francesconi, Gastone Castellani, Nicola Neretti, Jennifer A Sanders, John Sedivy, Philip A Gruppuso
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9084 (2010)
We investigated mTOR regulation of gene expression by studying rapamycin effect in two hepatic cell lines, the non-tumorigenic WB-F344 cells and the tumorigenic WB311 cells. The latter are resistant to the growth inhibitory effects of rapamycin, thus
Externí odkaz:
https://doaj.org/article/50bad68356c34aff9b3226be25394efa
Autor:
Rosa H Jimenez, Joan M Boylan, Ju-Seog Lee, Mirko Francesconi, Gastone Castellani, Jennifer A Sanders, Philip A Gruppuso
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7373 (2009)
The mTOR inhibitor rapamycin has anti-tumor activity across a variety of human cancers, including hepatocellular carcinoma. However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin
Externí odkaz:
https://doaj.org/article/75a94e2599c843808e5fbcda24d0ed0f
Publikováno v:
Obstetrics & Gynecology. 140:408-411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66766c445edf81a48ca8cb446065dc15
https://doi.org/10.1097/aog.0000000000004893
https://doi.org/10.1097/aog.0000000000004893
Autor:
Max Petersen, Anna Chorzalska, Makayla Pardo, Anaelena Rodriguez, John Morgan, Nagib Ahsan, Ting C. Zhao, Olin Liang, Leszek Kotula, Paul Bertone, Philip A. Gruppuso, Patrycja M. Dubielecka
Publikováno v:
Molecular Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::578e1353840b113a9f78c53e2cec5c9e
https://doi.org/10.1002/1878-0261.13374
https://doi.org/10.1002/1878-0261.13374
Autor:
Eli Y. Adashi, Philip A. Gruppuso
Publikováno v:
Mayo Clinic Proceedings. 97:1771-1773
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81163d4118cf8724b654fab53e233fd4
https://doi.org/10.1016/j.mayocp.2022.07.002
https://doi.org/10.1016/j.mayocp.2022.07.002