Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Philip A Gottlieb"'
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207309 (2018)
PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and E2117A.
Externí odkaz:
https://doaj.org/article/569bcb0c660447f9baf30f4189d3b3c0
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151289 (2016)
PIEZO1 is a mechanosensitive eukaryotic cation-selective channel that rapidly inactivates in a voltage-dependent manner. We previously showed that a fluorescent protein could be encoded within the hPIEZO1 sequence without loss of function. In this wo
Externí odkaz:
https://doaj.org/article/cb3209a747334edea5cc65bc15f82598
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125503 (2015)
Members of the eukaryotic PIEZO family (the human orthologs are noted hPIEZO1 and hPIEZO2) form cation-selective mechanically-gated channels. We characterized the selectivity of human PIEZO1 (hPIEZO1) for alkali ions: K+, Na+, Cs+ and Li+; organic ca
Externí odkaz:
https://doaj.org/article/0470e082561b4c6f9959640422473e33
Autor:
David H Vandorpe, Chang Xu, Boris E Shmukler, Leo E Otterbein, Marie Trudel, Frederick Sachs, Philip A Gottlieb, Carlo Brugnara, Seth L Alper
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8732 (2010)
Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca(2+)] ([Ca(2+)](i)) and subsequent activation of K(Ca) 3.1. The resulting erythrocyte volume decrease e
Externí odkaz:
https://doaj.org/article/3c1e62e6debf40fdaaebb7f07b9af453
Autor:
Eriko Katsuta, Kazuaki Takabe, Marija Vujcic, Philip A. Gottlieb, Tao Dai, Arnaldo Mercado-Perez, Arthur Beyder, Qingfei Wang, Mateusz Opyrchal
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9909 (2022)
Background: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca2+ channels, and cell depolarization. This study aimed to investigate PIEZO2’s role in breast cancer. Methods: The clinical relevance of PIEZO2 e
Externí odkaz:
https://doaj.org/article/feb3eaebe3f94456952378ab47d0d4c6
Autor:
Charles D. Cox, Philip A. Gottlieb
Publikováno v:
Biochemical Society Transactions. 47:1833-1842
PIEZO proteins are large eukaryotic mechanically-gated channels that function as homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles into a protein–lipid dome. A curved lipid region allows for the transition to th
Autor:
Pietro Ridone, Boris Martinac, Massimo Vassalli, Alexander Macmillan, Philip A. Gottlieb, Elvis Pandzic, Charles D. Cox
Publikováno v:
The Journal of General Physiology
The essential mammalian mechanosensitive channel PIEZO1 organizes in the plasma membrane into nanometric clusters that depend on the integrity of cholesterol domains to rapidly detect applied force and especially inactivate synchronously, the most co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d508c5110d4e61465ce707a2d3b1c02f
https://eprints.gla.ac.uk/219108/1/219108.pdf
https://eprints.gla.ac.uk/219108/1/219108.pdf
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Traumatic brain injury (TBI) elevates Abeta (Aβ) peptides in the brain and cerebral spinal fluid. Aβ peptides are amphipathic molecules that can modulate membrane mechanics. Because the mechanosensitive cation channel PIEZO1 is gated by membrane te
Publikováno v:
Journal of Cell Science.
The cell nucleus responds to mechanical cues with changes in size, morphology and motility. Previous work has shown that external forces couple to nuclei through the cytoskeleton network, but we show here that changes in nuclear shape can be driven s
Autor:
Radhakrishnan Gnanasambandam, Paulo Augusto Achucarro Silveira, David H. Vandorpe, Immacolata Andolfo, Carlo Brugnara, Nelson Hamerschlak, Seth L. Alper, Alicia Rivera, Philip A. Gottlieb, L. Michael Snyder, Boris E. Shmukler, Achille Iolascon
Publikováno v:
HemaSphere, Vol 2, Iss 5, p e55 (2018)
Hemasphere
Hemasphere
Supplemental Digital Content is available in the text.