Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Philip A Charles"'
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Autor:
Simon Davis, Connor Scott, Janina Oetjen, Philip D. Charles, Benedikt M. Kessler, Olaf Ansorge, Roman Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for u
Externí odkaz:
https://doaj.org/article/a9c62d9e72e54c4baedf487a7e9f1c8a
Autor:
Frederick D. Seward, Philip A. Charles
Capturing the excitement and accomplishments of X-ray astronomy, this second edition now includes a broader range of astronomical phenomena and dramatic new results from the most powerful X-ray telescopes. Covering all areas of astronomical research,
Autor:
Cyriel S. Olie, Muhammad Riaz, Rebecca Konietzny, Philip D. Charles, Adan Pinto-Fernandez, Szymon M. Kiełbasa, A. Aartsma-Rus, Jelle J. Goeman, Benedikt M. Kessler, Vered Raz
Publikováno v:
iScience, Vol 12, Iss , Pp 318-332 (2019)
Summary: Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compa
Externí odkaz:
https://doaj.org/article/5dae7c2a66fa4fae87860ea79e03a0f4
Autor:
Alexander G. Thompson, Elizabeth Gray, Philip D. Charles, Michele T. M. Hu, Kevin Talbot, Roman Fischer, Benedikt M. Kessler, Martin R. Turner
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
BackgroundAmyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterized by TDP-43 pathology. The identification in CSF of a protein signature of TDP-43 network dysfunction would ha
Externí odkaz:
https://doaj.org/article/0898164705254cd5a533d815022ed039
Autor:
Emily Feneberg, David Gordon, Alexander G. Thompson, Mattéa J. Finelli, Ruxandra Dafinca, Ana Candalija, Philip D. Charles, Imre Mäger, Matthew J. Wood, Roman Fischer, Benedikt M. Kessler, Elizabeth Gray, Martin R. Turner, Kevin Talbot
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105050- (2020)
TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant
Externí odkaz:
https://doaj.org/article/d8e57a13e21d47cfb4d7b1b8b23465d9
Autor:
Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson
Publikováno v:
eLife, Vol 9 (2020)
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E
Externí odkaz:
https://doaj.org/article/1e66b996a9fb4681a2ea07de56be7231
Autor:
Vincent Geoghegan, Kirsty Stainton, Stephanie M. Rainey, Thomas H. Ant, Adam A. Dowle, Tony Larson, Svenja Hester, Philip D. Charles, Benjamin Thomas, Steven P. Sinkins
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue viru
Externí odkaz:
https://doaj.org/article/942fa8266843463fb169fb68685ce5c2
Autor:
Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler, Keith M. Channon
Publikováno v:
Clinical Proteomics, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding and clinical manageme
Externí odkaz:
https://doaj.org/article/035c22cba2c84993b86234865bd4a996
Autor:
Adán Pinto-Fernández, Simon Davis, Abigail B. Schofield, Hannah C. Scott, Ping Zhang, Eidarus Salah, Sebastian Mathea, Philip D. Charles, Andreas Damianou, Gareth Bond, Roman Fischer, Benedikt M. Kessler
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been recognized as pharmacological targets in oncology, immunological disorders, and neurodegeneration. Mass spectrometry technology has now reached the capacity to cover th
Externí odkaz:
https://doaj.org/article/b456dfbb44a84b51b6b1b0b1ae1a0735