Výsledky vyhledávání - "Philip A, Read"

Chronic Dipeptidyl Peptidase-4 Inhibition With Sitagliptin Is Associated With Sustained Protection Against Ischemic Left Ventricular Dysfunction in a Pilot Study of Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease

Autor: Philip A. Read, Simon Bond, Liam Ring, Stephen P. Hoole, David P. Dutka, Anna C. Kydd, Liam M. McCormick

Publikováno v: Circulation: Cardiovascular Imaging. 7:274-281

Background— The incretin hormone, glucagon-like peptide-1, promotes myocardial glucose uptake and may improve myocardial tolerance to ischemia. Endogenous glucagon-like peptide-1 (7–36) is augmented by pharmacological inhibition of dipeptidyl pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39e195893160bf35a0c89477df41b0
https://doi.org/10.1161/circimaging.113.000785

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Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

Autor: Adam J. Brown, Philip A. Read, Joel P. Giblett, Paul A. White, Richard G. Axell, Michael O'Sullivan, Nick E.J. West, David P. Dutka, Liam M. McCormick, Stephen P. Hoole, Sophie J. Clarke, Johannes Reinhold

Publikováno v: Cardiovascular Diabetology

Background Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4053be0c4136d3d8661552d06692a31c
https://doi.org/10.1186/s12933-016-0416-3

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Coronary collaterals provide a constant scaffold effect on the left ventricle and limit ischemic left ventricular dysfunction in humans

Autor: P White, David P. Dutka, Philip A. Read, Patrick M. Heck, Nick E.J. West, Michael O'Sullivan, Stephen P. Hoole

Publikováno v: Journal of Applied Physiology. 112:1403-1409

Coronary collaterals preserve left ventricular (LV) function during coronary occlusion by reducing myocardial ischemia and may directly influence LV compliance. We aimed to re-evaluate the relationship between coronary collaterals, measured quantitat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5d11bdaa1a4c6ae9d9b6df9b1edd5a
https://doi.org/10.1152/japplphysiol.01304.2011

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Targeted Left Ventricular Lead Placement to Guide Cardiac Resynchronization Therapy

Autor: Simon P. Fynn, Fakhar Z. Khan, Philip A. Read, David P. Dutka, David Begley, Peter J. Pugh, Mumohan S. Virdee, Denis O’Halloran, Christopher R. Palmer, Maros Elsik

Publikováno v: Journal of the American College of Cardiology. 59:1509-1518

Objectives This study sought to assess the impact of targeted left ventricular (LV) lead placement on outcomes of cardiac resynchronization therapy (CRT). Background Placement of the LV lead to the latest sites of contraction and away from the scar c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a3b10d23eb71f338608912881f358f
https://doi.org/10.1016/j.jacc.2011.12.030

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Cardiac Resynchronization Therapy Optimization Using Noninvasive Cardiac Output Measurement

Autor: Simon P. Fynn, Philip A. Read, Fakhar Z. Khan, Beverley Smith, David P. Dutka, John Hutchinson, Peter J. Pugh, Munmohan Virdee

Publikováno v: Pacing and Clinical Electrophysiology. 34:1527-1536

Aims: Noninvasive cardiac output (CO) measurement (NICOM) is a novel method to assess ventricular function and offers a potential alternative for optimization of cardiac resynchronization therapy (CRT) devices. We compared the effect of NICOM-based o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::993018ea5c33edb96c0e82f97b6f93df
https://doi.org/10.1111/j.1540-8159.2011.03172.x

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Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease

Autor: Philip A. Read, Fakhar Z. Khan, David P. Dutka

Publikováno v: Heart. 98:408-413

Glucagon-like peptide-1 (GLP-1) is an incretin hormone which has been shown to promote myocardial glucose uptake. Its pharmacological properties as a cardioprotective agent are attractive because it has a short half-life and there is minimal risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf83b56351dcc7ed85842b04977c51af
https://doi.org/10.1136/hrt.2010.219345

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Impact of VV optimization in relation to left ventricular lead position: an acute haemodynamic study

Autor: Munmohan Virdee, Fakhar Z. Khan, Philip A. Read, David Begley, David P. Dutka, Peter J. Pugh, Simon P. Fynn

Publikováno v: Europace. 13:845-852

Aims Left ventricular (LV) lead placement to the most delayed segment offers the greatest potential benefit to cardiac resynchronization therapy (CRT). We assessed the impact of interventricular (VV) optimization on acute changes in cardiac output (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c874f635adfec0d22503d5f3cf7996a
https://doi.org/10.1093/europace/eur037

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The Impact of the Right Ventricular Lead Position on Response to Cardiac Resynchronization Therapy

Autor: Munmohan Virdee, Peter J. Pugh, Philip A. Read, Pegah Salahshouri, Maros Elsik, David Begley, Simon P. Fynn, Fakhar Z. Khan, David P. Dutka, Rudy Duehmke

Publikováno v: Pacing and Clinical Electrophysiology. 34:467-474

Introduction: Left ventricular (LV) lead placement to the latest contracting area (concordant LV lead) is associated with better response to cardiac resynchronization therapy (CRT) compared to a discordant LV lead. However, the effect of the right ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01c21bff4e25b3ae5eee84c6d394bd2a
https://doi.org/10.1111/j.1540-8159.2010.02995.x

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Stunning and Cumulative Left Ventricular Dysfunction Occurs Late After Coronary Balloon Occlusion in Humans

Autor: Nick E.J. West, David P. Dutka, Sadia N. Khan, Philip A. Read, Patrick M. Heck, Michael O'Sullivan, Stephen P. Hoole, P White

Publikováno v: JACC: Cardiovascular Interventions. 3(4):412-418

Objectives We aimed to investigate whether left ventricular (LV) stunning could be detected late after coronary occlusion when coronary flow has normalized. Background Stunning and cumulative LV dysfunction after ischemia reperfusion has been clearly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74751d40a85bcf22afd952afb9d4844

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Non-invasive cardiac output measurements based on bioreactance for optimization of atrio- and interventricular delays

Autor: Munmohan Virdee, Fakhar Z. Khan, Peter J. Pugh, Philip A. Read, Simon P. Fynn, David P. Dutka

Publikováno v: Europace. 11:1666-1674

Non-invasive cardiac output monitoring (NICOM) based on bio-reactance offers a portable method to assess ventricular function. Optimization of cardiac resynchronization therapy (CRT) by echocardiography is labour-intensive. We compared the ability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee51da83d1732b13165b1a0da51b2f45
https://doi.org/10.1093/europace/eup358

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