Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Philip A, Barker"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Axons that are physically separated from their soma activate a series of signaling events that results in axonal self-destruction. A critical element of this signaling pathway is an intra-axonal calcium rise that occurs just prior to axonal fragmenta
Externí odkaz:
https://doaj.org/article/8cbc0899b67144349baef6a42e2ad8ed
Autor:
Léa Décarie-Spain, Sandeep Sharma, Cécile Hryhorczuk, Victor Issa-Garcia, Philip A. Barker, Nathalie Arbour, Thierry Alquier, Stephanie Fulton
Publikováno v:
Molecular Metabolism, Vol 10, Iss , Pp 1-13 (2018)
Objective: The incidence of depression is significantly compounded by obesity. Obesity arising from excessive intake of high-fat food provokes anxiodepressive behavior and elicits molecular adaptations in the nucleus accumbens (NAc), a region well-im
Externí odkaz:
https://doaj.org/article/5ec53836b3784b6a8a87aba1d3c74c61
Publikováno v:
J Neurosci
The activation of self-destructive cellular programs helps sculpt the nervous system during development, but the molecular mechanisms used are not fully understood. Prior studies have investigated the role of the APP in the developmental degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3463a4ac007dafe9282566d85fa23a5
https://doi.org/10.1523/jneurosci.0162-22.2022
https://doi.org/10.1523/jneurosci.0162-22.2022
Autor:
Marcela Laura Chaki Borrás, Georgia Colbran, David R. G. Mitchell, Philip J. Barker, Ronald Sluyter, Konstantin Konstantinov
Publikováno v:
Journal of Biomedical Materials Research Part A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d575acc7f7a3b9946fb1b422c72edf85
https://doi.org/10.1002/jbm.a.37524
https://doi.org/10.1002/jbm.a.37524
Autor:
Andrew C. Smith, Peter M. Wynn, Philip A. Barker, Melanie J. Leng, Steve R. Noble, Andrew Stott
Publikováno v:
International Journal of Speleology, Vol 45, Iss 1, Pp 1-9 (2016)
Palaeoclimate records from northern Iberia are becoming increasingly sought after as this region is one of the most southerly terrestrial locations in Europe to have its climate dictated principally by the North Atlantic. Terrestrial records therefor
Externí odkaz:
https://doaj.org/article/f4279ff07de0454faf75122d52432640
Autor:
Aaron D Johnstone, Robin M Hallett, Andrés de Léon, Bruno Carturan, Julien Gibon, Philip A Barker
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199570 (2018)
Axons normally degenerate during development of the mammalian nervous system, but dysregulation of the same genetically-encoded destructive cellular machinery can destroy crucial structures during adult neurodegenerative diseases. Nerve growth factor
Externí odkaz:
https://doaj.org/article/6268038ca52446609ffc32b01461f43d
Publikováno v:
Cell Reports, Vol 4, Iss 4, Pp 751-763 (2013)
Our knowledge of the destructive events that regulate axonal degeneration is rudimentary. Here, we examine the role of caspases and their endogenous inhibitor, the X-linked inhibitor of apoptosis protein (XIAP), in axonal degeneration of dorsal root
Externí odkaz:
https://doaj.org/article/d0d1832451b742b99b7346a3a88e78f7
Autor:
Perrine Gaub, Andrès de Léon, Julien Gibon, Vincent Soubannier, Geneviève Dorval, Philippe Séguéla, Philip A Barker
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150601 (2016)
Neurotrophins activate intracellular signaling pathways necessary for neuronal survival, growth and apoptosis. The most abundant neurotrophin in the adult brain, brain-derived neurotrophic factor (BDNF), is first synthesized as a proBDNF precursor an
Externí odkaz:
https://doaj.org/article/9ec6215505df4cf3be85d54172e79ee7
Publikováno v:
Journal of Pain Research. 13:1223-1241
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation, and survival of sympathetic and sensory afferent neurons during development. A substantial body of evidence, based on both animal and human studies, demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3886bf05ae8c02fd246ac822a71e78b3
https://doi.org/10.2147/jpr.s247472
https://doi.org/10.2147/jpr.s247472
Autor:
Yaser Rehman, Alexander Morlando, Vitor Sencadas, Philip J. Barker, Konstantin Konstantinov, Jared McNamara
Publikováno v:
Journal of Materials Science. 55:8095-8108
The use of TiO2 nanoparticles in sunscreen products has raised concern over their oxidative potential and adverse health effects brought about by their propensity to produce free radicals when exposed to UV radiation. In this study, an investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca03dcd162a5a4819af819329f9d1e9
https://doi.org/10.1007/s10853-020-04598-3
https://doi.org/10.1007/s10853-020-04598-3