Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Philip Tinnefeld"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Allostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems. We use a DN
Externí odkaz:
https://doaj.org/article/3c32d3a2a3174d209f2c7bc6e8675c63
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Catch bonds are a rare class of protein-protein interactions where the bond lifetime increases under an external pulling force. Here, we report how modification of anchor geometry generates catch bonding behavior for the mechanostable Docker
Externí odkaz:
https://doaj.org/article/ee6d55f38bb9443d821c24403293a281
Autor:
Rosa Antón, Miguel Á. Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J. Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M. Vera, Javier Oroz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction and contribute to a significant number of incurable human diseases. Scarce structural insights available on disease-related homorepeat expansions hinder
Externí odkaz:
https://doaj.org/article/3794aa1413964515962ab2aa2be23a71
Autor:
Simon Wanninger, Pooyeh Asadiatouei, Johann Bohlen, Clemens-Bässem Salem, Philip Tinnefeld, Evelyn Ploetz, Don C. Lamb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Single-molecule experiments have changed the way we explore the physical world, yet data analysis remains time-consuming and prone to human bias. Here, we introduce Deep-LASI (Deep-Learning Assisted Single-molecule Imaging analysis), a softw
Externí odkaz:
https://doaj.org/article/e1fe197473194049b53352200f89a7f4
Autor:
Jonas Zähringer, Fiona Cole, Johann Bohlen, Florian Steiner, Izabela Kamińska, Philip Tinnefeld
Publikováno v:
Light: Science & Applications, Vol 12, Iss 1, Pp 1-8 (2023)
Super-resolution microscopy with 3 nm resolution and sub-nanometer localization precision is achieved on DNA origami structures with DNA PAINT and L-PAINT, a novel scheme for fast super-resolution.
Externí odkaz:
https://doaj.org/article/235c2887959b44b6b4ca962245961b2c
Autor:
Gordon J. Hedley, Tim Schröder, Florian Steiner, Theresa Eder, Felix J. Hofmann, Sebastian Bange, Dirk Laux, Sigurd Höger, Philip Tinnefeld, John M. Lupton, Jan Vogelsang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Photon antibunching typically measures the time-averaged photophysics of multichromophoric nanoparticles. Here, the authors report on time-resolving photon antibunching, allowing the true number of chromophores and exciton diffusion to be measured in
Externí odkaz:
https://doaj.org/article/4114e7ead71744eb9b48e3b6a3936e40
Autor:
Kateryna Trofymchuk, Viktorija Glembockyte, Lennart Grabenhorst, Florian Steiner, Carolin Vietz, Cindy Close, Martina Pfeiffer, Lars Richter, Max L. Schütte, Florian Selbach, Renukka Yaadav, Jonas Zähringer, Qingshan Wei, Aydogan Ozcan, Birka Lalkens, Guillermo P. Acuna, Philip Tinnefeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Single-molecule fluorescence currently requires specialized imaging equipment due to the low signal of a single emitter. Here the authors introduce NanoAntennas with Cleared HOtSpots (NACHOS) to boost the signal sufficient for detection of a single e
Externí odkaz:
https://doaj.org/article/9db22d60e3b94597a65b769a9d0fd002
Autor:
Zhaowei Liu, Haipei Liu, Andrés M. Vera, Rafael C. Bernardi, Philip Tinnefeld, Michael A. Nash
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Understanding bacterial adhesion is important in a number of different areas of study. Here using a range of simulations and experimental methods, the authors, report on the molecular mechanism behind the binding of bacteria to cellulose fibers at hi
Externí odkaz:
https://doaj.org/article/d2e3460e62474fa69f169c914a4432c2
Autor:
Kevin Kramm, Tim Schröder, Jerome Gouge, Andrés Manuel Vera, Kapil Gupta, Florian B. Heiss, Tim Liedl, Christoph Engel, Imre Berger, Alessandro Vannini, Philip Tinnefeld, Dina Grohmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
TATA-binding protein (TBP) and a transcription factor (TF) IIB-like factor are important constituents of all eukaryotic initiation complexes. Here, the authors use a DNA origami-based force clamp to investigate the assembly dynamics of human initiati
Externí odkaz:
https://doaj.org/article/6c52a4bb73744eafa2b7a2b2daca7321
Autor:
Martina Pfeiffer, Kateryna Trofymchuk, Simona Ranallo, Francesco Ricci, Florian Steiner, Fiona Cole, Viktorija Glembockyte, Philip Tinnefeld
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103072- (2021)
Summary: DNA nanotechnology offers new biosensing approaches by templating different sensor and transducer components. Here, we combine DNA origami nanoantennas with label-free antibody detection by incorporating a nanoswitch in the plasmonic hotspot
Externí odkaz:
https://doaj.org/article/bc56764a874446e9ae707e4cb93a0723