Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Philip Peach"'
Autor:
Steven J. Fussell, Craig J. Knight, Michael Hawksworth, Daniel Laity, Suju Mathew, Samantha V. Oke, Philip Peach, David S. B. Daniels, Olivier Dirat, Robert Crook, Adam Gymer, Samantha Prior
Publikováno v:
Organic Process Research & Development. 25:2686-2692
A change in facility for the synthesis of the step 2 intermediate for talazoparib tosylate (1·TsOH) required the development of an alternative, intrinsically safer process. Rapid route scouting and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1124bef7ea76a5fb8e305d8553bf7b96
https://doi.org/10.1021/acs.oprd.1c00259
https://doi.org/10.1021/acs.oprd.1c00259
Autor:
Oliver J. Kershaw, Adam D. Clayton, Jamie A. Manson, Alexandre Barthelme, John Pavey, Philip Peach, Jason Mustakis, Roger M. Howard, Thomas W. Chamberlain, Nicholas J. Warren, Richard A. Bourne
Publikováno v:
Chemical Engineering Journal. 451:138443
The consideration of discrete variables (e.g. catalyst, ligand, solvent) in experimental self-optimisation approaches remains a significant challenge. Herein we report the application of a new mixed variable multi-objective optimisation (MVMOO) algor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676d0a2b48238d075fd289b3e8a46ccd
https://doi.org/10.1016/j.cej.2022.138443
https://doi.org/10.1016/j.cej.2022.138443
Publikováno v:
Tetrahedron Letters. 53:948-951
4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a key intermediate in the synthesis of Crizotinib. We report a robust three-step synthesis that has successfully delivered multi-kilogram quantities of the key intermediate. The process includes nucleophilic ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c085d4409f522e9a4474d5d4ecf2f7e
https://doi.org/10.1016/j.tetlet.2011.12.044
https://doi.org/10.1016/j.tetlet.2011.12.044
Autor:
Jean-Philippe Crochard, Melissa Birch, Amy Luan, Jinu S. Mathew, Philip Peach, Neil McDowall, David Sebastien Fradet, Stephen Challenger, Kevin Meldrum, Charles M. Gordon, Hayley Jackman, Stephen Yeo, Evelyn Madigan
Publikováno v:
Organic Process Research & Development. 15:1358-1364
The development of a highly efficient two-step process for the manufacture of the α2δ-ligand imagabalin hydrochloride 1 is described in 50% overall yield from (R)-3-methylhexanoic acid 2. Key aspec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9685f05fa65964e82bc79b3bfd7a2f4a
https://doi.org/10.1021/op2002326
https://doi.org/10.1021/op2002326
Publikováno v:
Organic Process Research & Development. 15:1124-1129
An improved, simpler and potentially more economical route to (S)-N-Boc-2,6-dimethyltyrosine 1, based on a previously published route, is presented. Key modifications were to prepare the dehydroaminoacid hydrogenation substrate 6 in a one-pot process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7abac41717ed6a7fa0187785bde2e92
https://doi.org/10.1021/op200065p
https://doi.org/10.1021/op200065p
Autor:
Claire Chadwick, Philip Peach, Matthew Badland, Joe WaiChiu Cheung, Steven J. Fussell, Daniel Laity, David Shaw, Robert J. Carroll
Publikováno v:
Tetrahedron: Asymmetry. 22:1328-1331
An enantioselective synthesis of (R)- and (S)-3-amino-7-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one via an asymmetric reduction and spontaneous cyclisation is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba301d42b798814586686155f1504bc8
https://doi.org/10.1016/j.tetasy.2011.07.021
https://doi.org/10.1016/j.tetasy.2011.07.021
Autor:
Lynne Campbell, Inderjit Singh Mann, Martin Wills, David J. Cross, Ian Houson, Philip Peach, Jennifer A. Kenny, Tim Walsgrove
Publikováno v:
Tetrahedron. 62:1864-1876
Asymmetric transfer hydrogenation of cyclic and acyclic α,β-unsaturated ketones catalysed by η 6 - p -cymene/ruthenium(II) and η 5 -pentamethylcyclopentadienyl/rhodium(III) complexes have been investigated. Cyclic α,β-unsaturated ketones appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7bd070972347a2a1171669fbd8a9043
https://doi.org/10.1016/j.tet.2005.11.036
https://doi.org/10.1016/j.tet.2005.11.036
Publikováno v:
Tetrahedron: Asymmetry. 13:2485-2490
A range of 1-aryl-2-tetranols, and 1-phenyl-2-indanol, have been generated in high yield and enantiomeric excess from the corresponding racemic ketones, via a dynamic kinetic resolution–transfer hydrogenation process, using Ru(II)-TsDPEN in formic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2140ebdd82d5c07b7d3356e985be7b2c
https://doi.org/10.1016/s0957-4166(02)00648-1
https://doi.org/10.1016/s0957-4166(02)00648-1
Autor:
David J. Cross, Jennifer A. Kenny, Philip Peach, Tim Walsgrove, Jérôme Hannedouche, Inderjit Singh Mann, Lynne Campbell, Ian Houson, Martin Wills
Publikováno v:
Tetrahedron. 62:5549
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3a10a00770bf7ad114f25a41453bcd
https://doi.org/10.1016/j.tet.2006.03.054
https://doi.org/10.1016/j.tet.2006.03.054
Autor:
Melissa Birch, Stephen Challenger, Jean-Philippe Crochard, David Fradet, Hayley Jackman, Amy Luan, Evelyn Madigan, Jinu S. Mathew, Neil McDowall, Kevin Meldrum, Charles M. Gordon, Philip Peach, Stephen Yeo
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1358-1364, 7p