Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Philip P. Chamberlain"'
Autor:
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into th
Externí odkaz:
https://doaj.org/article/16ac1202277e490cac61cc68b1c66fb7
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Table 1. Proteomic data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680350b5736d467704658c272205ed4c
https://doi.org/10.1158/2643-3230.22543710.v1
https://doi.org/10.1158/2643-3230.22543710.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Supplementary Methods, Figures, and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08d3edb19dfbd0f47523bcd0445d5d1
https://doi.org/10.1158/2643-3230.22543713.v1
https://doi.org/10.1158/2643-3230.22543713.v1
Autor:
Benjamin L. Ebert, Steven A. Carr, Philip P. Chamberlain, Mark Rolfe, Jean-Michel Cayuela, Jean-Jacques Kiladjian, Stéphane De Botton, Véronique Saada, Christophe Marzac, Sophie Cotteret, Rob S. Sellar, Andrew A. Guirguis, Alexander Tepper, Kaushik Viswanathan, Marie McConkey, Thomas Clayton, Mary E. Matyskiela, Namrata D. Udeshi, Pierre M. Jean Beltran, Daniel E. Grinshpun, Jessica A. Gasser, Aline Renneville
Thalidomide analogues exert their therapeutic effects by binding to the CRL4CRBN E3 ubiquitin ligase, promoting ubiquitination and subsequent proteasomal degradation of specific protein substrates. Drug-induced degradation of IKZF1 and IKZF3 in B-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eb4d478e4fdb51c5ac5ce49a6e60d1
https://doi.org/10.1158/2643-3230.c.6550374.v1
https://doi.org/10.1158/2643-3230.c.6550374.v1
Publikováno v:
Annual Review of Cancer Biology. 5:181-201
Many essential biological processes are regulated through proximity, from membrane receptor signaling to transcriptional activity. The ubiquitin-proteasome system controls protein degradation, with ubiquitin ligases as the rate-limiting step. Ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920bcfb1b4c737867e921633914ccab4
https://doi.org/10.1146/annurev-cancerbio-051420-114114
https://doi.org/10.1146/annurev-cancerbio-051420-114114
Autor:
Joshua Hansen, John E. Dick, Philip P Chamberlain, Emily Rychak, Gang Lu, In Sock Jang, Jean C.Y. Wang, Thomas Clayton, Celia Fontanillo, Derek Mendy, Michael Pourdehnad, Jinhong Fan, Stanley W.K. Ng, Eileen Tran, Mark Rolfe, Nathan Mbong, Kai Wang, Chin-Chun Lu, James Carmichael, Christine Surka, Mary E Matyskiela, Daniel W. Pierce, Mark D. Minden, Liqing Jin, Antonia Lopez-Girona, Brian E. Cathers, Elizabeth Anne Tindall, Adrian Contreras, Christy Hsu
Publikováno v:
Blood. 137:661-677
A number of clinically validated drugs have been developed by repurposing the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex with molecular glue degraders to eliminate disease-driving proteins. Here, we present the identification of a fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390854bdb0e3f67bbd5f3627b5b5ffe5
https://doi.org/10.1182/blood.2020008676
https://doi.org/10.1182/blood.2020008676
Autor:
Edmond R. Watson, Scott J. Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres Hernandez de la Peña, Jin-Yi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander
Cereblon (CRBN) is an ubiquitin ligase (E3) adaptor protein co-opted by CRBN E3 Ligase Modulatory Drugs (CELMoD) agents that target therapeutically-relevant proteins for degradation. Prior crystallographic studies defined the drug-binding site within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6725d3acc0caf347d97d1c4f855d6401
https://doi.org/10.1101/2022.07.02.498551
https://doi.org/10.1101/2022.07.02.498551
Autor:
Dan Rozelle, Fadi Towfic, Erin Flynt, Maria Ortiz Estevez, Paula Dhiman, Naser Ansari-Pour, Marissa Hirst, Anjan Thakurta, Kao-Tai Tsai, Karthik Ramasamy, Paola Neri, Nizar J. Bahlis, Paresh Vyas, Philip P Chamberlain, Sarah Gooding
Publikováno v:
Blood
Emergence of drug resistance to all available therapies is the major challenge to improving survival in myeloma. Cereblon (CRBN) is the essential binding protein of the widely used immunomodulatory drugs (IMiDs) and novel CRBN E3 ligase modulator dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbdd09ae09632ffc0faa9aad0f2c8ff
https://doi.org/10.1182/blood.2020007081
https://doi.org/10.1182/blood.2020007081
Autor:
Mary E Matyskiela, Thomas Clayton, Philip P Chamberlain, Aaron Carpenter, Mark Rolfe, Barbra Pagarigan, Joseph J. McDonald, Gang Lu, Eileen Tran, Christopher Mayne, Lawrence G Hamann, Xinde Zheng
Publikováno v:
Nature Structural & Molecular Biology. 27:319-322
Thalidomide-dependent degradation of the embryonic transcription factor SALL4 by the CRL4CRBN E3 ubiquitin ligase is a plausible major driver of thalidomide teratogenicity. The structure of the second zinc finger of SALL4 in complex with pomalidomide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7210984ec5e6072f87bb4c0493f947fc
https://doi.org/10.1038/s41594-020-0405-9
https://doi.org/10.1038/s41594-020-0405-9
Autor:
Philip P Chamberlain, David Mikolon, Ho Cho, Johnson Jeffrey C, Mahan Abbasian, Nadia Ladygina, Nicolas Villanueva, Hadjivassiliou Haralambos, Richard Y.-C. Huang, Gustavo Fenalti, Alok Sharma, Dan Zhu, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Kandasamy Hariharan, Mark Griffith
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8c511046adf13fd6850c565f111f03
https://doi.org/10.1038/s41467-021-25475-w
https://doi.org/10.1038/s41467-021-25475-w