Zobrazeno 1 - 10
of 746
pro vyhledávání: '"Philip Cohen"'
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss 1 (2023)
Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a
Externí odkaz:
https://doaj.org/article/c92e6312a63543708b07becc97dd9975
Autor:
Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap, we used a combinati
Externí odkaz:
https://doaj.org/article/612ab4473bc34e1f9a8c8690879295a3
Autor:
Philip Cohen
Publikováno v:
Social Determinants of Health, Vol 8, Iss 1 (2022)
Background: Wearing high-heeled shoes is associated with injury risk. During the COVID-19 pandemic, changes in work and social behavior may have reduced women’s use of such footwear. The aim of the study was to investigate how the trend in high-hee
Externí odkaz:
https://doaj.org/article/d973e265bff3475194008e6cee83eea8
Autor:
Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express n
Externí odkaz:
https://doaj.org/article/9aa94b8e1ece4432939106c9866a2b7e
Autor:
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/c56070943eee409893dfc8b9a45018c9
Autor:
Philip, Cohen
Publikováno v:
IUBMB Life. 75:284-288
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
Publikováno v:
Biochemical Journal. 479:1891-1907
A conditional knock-in mouse was generated in which the TAK1 catalytic subunit was largely replaced by the kinase-inactive TAK1[D175A] mutant in immune cells. The activation of p38α MAP kinase, c-Jun N-terminal kinases 1 and 2 (JNK1/2) and the canon
Autor:
Alina Puig, Stephen Philip Cohen, Rachel Koch Bach, Adriana Arciniegas Leal, Osman Gutierrez, Bryan Bailey
Publikováno v:
PhytoFrontiers™.
Frosty pod rot (FPR), caused by Moniliophthora roreri (MR), is one of the most important diseases of cacao, causing losses of up to 90% in areas where it is present. A limited number of resistant clones have been identified, but additional sources of
Autor:
Jason Leung, Stephen Philip Cohen, Indrani K. Baruah, Shahin S. Ali, Jonathan Shao, Yahaya Bukari, Ishmael Amoako-Attah, Lyndel W. Meinhardt, Bryan A. Bailey
Publikováno v:
PhytoFrontiers™.
Thread blight disease (TBD) is a serious emerging threat to global cacao production, causing leaf blight symptoms and necrosis in the canopy of infected trees. Though previously thought to be caused primarily by the fungus Marasmiellus scandens, rece
Publikováno v:
Le Praticien en Anesthésie Réanimation. 26:233-235