Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Philip G. Board"'
Autor:
Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke A.J. O’Neill
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 151-161.e5 (2019)
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyropto
Externí odkaz:
https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 549 (2021)
γ-Glutamyltransferase (GGT), a membrane-bound enzyme, contributes to the metabolism of glutathione (GSH), which plays a critical physiological role in protecting cells against oxidative stress. GGT has been proposed as a biomarker of carcinogenesis
Externí odkaz:
https://doaj.org/article/4072527e606042e3a6ef37f19ed7cb53
Autor:
Mark M. Hughes, Nilisha Fernando, Shuhei Takahashi, Padmaja Tummala, Melissa Rooke, Marco G. Casarotto, Jane E. Dahlstrom, Philip G. Board, Luke A. J. O'Neill
Publikováno v:
Carcinogenesis. 42:853-863
Inflammatory bowel disease (IBD) is characterized by multiple alterations in cytokine expression and is a risk factor for colon cancer. The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleuki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55294745611df6eef10f8a449c9f3e17
https://doi.org/10.1093/carcin/bgab008
https://doi.org/10.1093/carcin/bgab008
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162415 (2016)
The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II d
Externí odkaz:
https://doaj.org/article/6ed2d91727c74af68a1447490b4726f5
Autor:
Danny Rangasamy, P.-T. Chiou, Stephen J. Ohms, Marco G. Casarotto, Jane E. Dahlstrom, Philip G. Board
Publikováno v:
Clinical and Translational Oncology. 23:353-363
In contrast to hormone receptor driven breast cancer, patients presenting with triple-negative breast cancer (TNBC) often have limited drug treatment options. Efavirenz, a non-nucleoside reverse transcriptase (RT) inhibitor targets abnormally overexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1823aa3e586886f1f558f0161ad8be42
https://doi.org/10.1007/s12094-020-02424-5
https://doi.org/10.1007/s12094-020-02424-5
Autor:
Takeshi Yuasa, Kosuke Takemura, Gulanbar Amori, Philip G. Board, Kentaro Inamura, Junji Yonese, Fumitaka Koga
Publikováno v:
Targeted Oncology. 15:347-356
γ-Glutamyltransferase (GGT) is a marker of oxidative stress. Elevated serum GGT is linked to poor survival in various malignancies; however, there are no data on metastatic renal cell carcinoma (mRCC). Additionally, GGT expression in cancer tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2484d5af61353bb5f7a8f7998cd068b2
https://doi.org/10.1007/s11523-020-00719-9
https://doi.org/10.1007/s11523-020-00719-9
Autor:
Leon A. Sokulsky, Simon Keely, Philip G. Board, Paul S. Foster, Ming Yang, Simonne Sherwin, Gerard E. Kaiko, Fiona Eyers, Bridie J. Goggins
Publikováno v:
Clinical & Experimental Allergy. 50:609-624
BACKGROUND Glutathione S-transferases omega class 1 (GSTO1-1) is a unique member of the GST family regulating cellular redox metabolism and innate immunity through the promotion of LPS/TLR4/NLRP3 signalling in macrophages. House dust mite (HDM) trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cfdb809366501b1dd971a8b410f995
https://doi.org/10.1111/cea.13582
https://doi.org/10.1111/cea.13582
Autor:
Girdhar Singh Deora, Aaron J. Oakley, Philip G. Board, Yuji Nakano, Jayme L. Dahlin, Padmaja Tummala, Jonathan B. Baell, Jessica M. Strasser, Yiyue Xie, Michael A. Walters, Melissa Rooke, Matthew E. Cuellar, Marco G. Casarotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2894-2914
Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d34d91fc9b9fcdcb3312475033c026
https://doi.org/10.1021/acs.jmedchem.9b01391
https://doi.org/10.1021/acs.jmedchem.9b01391
Autor:
Pey-Tsyr Chiou, Stephen Ohms, Philip G. Board, Jane E. Dahlstrom, Danny Rangasamy, Marco G. Casarotto
Publikováno v:
Cancers; Volume 13; Issue 24; Pages: 6232
Cancers, Vol 13, Iss 6232, p 6232 (2021)
Cancers
Cancers, Vol 13, Iss 6232, p 6232 (2021)
Cancers
Simple Summary Cancer stem cells (CSCs) are responsible for tumour initiation, chemo- and radiotherapy resistance and cancer recurrence. CSCs display plasticity that enables them to alter their phenotype and function making them challenging to elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fc35b3e5ed6ed7b090feac311e83b2
Autor:
Philip G. Board, Takeshi Yuasa, Kosuke Takemura, Hiroshi Fukushima, Fumitaka Koga, Kentaro Inamura, Masaya Ito, Minami Une, Junji Yonese, Shuichiro Kobayashi
Publikováno v:
Cancers
Volume 13
Issue 21
Cancers, Vol 13, Iss 5587, p 5587 (2021)
Volume 13
Issue 21
Cancers, Vol 13, Iss 5587, p 5587 (2021)
Background: Reports on the prognostic significance of serum γ-glutamyltransferase (GGT) in men with metastatic castration-resistant prostate cancer (mCRPC) are limited. In addition, GGT expression status in cancer tissues has not been well character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1686680c4e1f6519d4a39788430000