Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Autor: Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven

Publikováno v: Hepatology

The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co-expressed with the MT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb94768e1a81ce10629a43080da15007
https://hdl.handle.net/1887/3502375

Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile

Autor: Antoine Rimbert, Ming W. Yeung, Nawar Dalila, Chris H.L. Thio, Haojie Yu, Natalia Loaiza, Federico Oldoni, Adriaan van der Graaf, Siqi Wang, M. Abdullah Said, Lisanne L. Blauw, Aurore Girardeau, Lise Bray, Amandine Caillaud, Vincent W. Bloks, Marie Marrec, Philippe Moulin, Patrick C.N. Rensen, Bart van de Sluis, Harold Snieder, Mathilde Di Filippo, Pim van der Harst, Anne Tybjaerg-Hansen, Philip Zimmerman, Bertrand Cariou, Jan Albert Kuivenhoven

Publikováno v: Rimbert, A, Yeung, M W, Dalila, N, Thio, C H L, Yu, H, Loaiza, N, Oldoni, F, van der Graaf, A, Wang, S, Said, M A, Blauw, L L, Girardeau, A, Bray, L, Caillaud, A, Bloks, V W, Marrec, M, Mouli, P, Rensen, P C N, van de Sluis, B, Snieder, H, Di Filippo, M, van der Harst, P, Tybjaerg-Hansen, A, Zimmerman, P, Cariou, B & Kuivenhoven, J A 2022, ' Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 42, no. 10, pp. 1262-1271 . https://doi.org/10.1161/ATVBAHA.122.317514
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2022, 42 (10), pp.1262-1271. ⟨10.1161/atvbaha.122.317514⟩
Arteriosclerosis, thrombosis, and vascular biology, 42(10), 1262-1271. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, Thrombosis, and Vascular Biology, 42(10), 1262-1271. LIPPINCOTT WILLIAMS & WILKINS

Background:In mice, GPR146 (G-protein–coupled receptor 146) deficiency reduces plasma lipids and protects against atherosclerosis. Whether these findings translate to humans is unknown.Methods:Common and rare genetic variants in theGPR146gene locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb70fea5501d89e9dcbe494d7a9b727
https://curis.ku.dk/ws/files/320753917/ATVBAHA.122.317514.pdf