Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Philip, Weidner"'
Autor:
Matthias P Ebert, ProfMD, Nadja M Meindl-Beinker, PhD, Tobias Gutting, MD, Martin Maenz, PhD, Johannes Betge, MD, Nadine Schulte, MD, Tianzuo Zhan, MD, Philip Weidner, MD, Elke Burgermeister, PhD, Ralf Hofheinz, ProfMD, Arndt Vogel, ProfMD, Stefan Angermeier, MD, Claus Bolling, MD, Maike de Wit, ProfMD, Ralf Jakobs, ProfMD, Meinolf Karthaus, ProfMD, Gertraud Stocker, MD, Peter Thuss-Patience, MD, Tobias Leidig, PhD, Timo Gaiser, ProfMD, Jakob N Kather, ProfMD, Nicolai Haertel, MD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e417-e427 (2022)
Summary: Background: The overall survival of patients with advanced and refractory oesophageal squamous cell carcinoma, mostly aged 65 years and older, is poor. Treatment with PD-1 antibodies showed improved progression-free survival and overall surv
Externí odkaz:
https://doaj.org/article/44c5e9f98cad4d8cb78f0b4c9de02298
Autor:
Isabel Porth, Daniela Hirsch, Yonca Ceribas, Philip Weidner, Wilko Weichert, Thorsten Oliver Götze, Sven Perner, Kim Luley, Christian Moritz Heyer, Carolina de la Torre, Ralf-Dieter Hofheinz, Sylvie Lorenzen, Timo Gaiser
Publikováno v:
European Journal of Cancer. 183:119-130
Background A subgroup of patients with HER2-positive metastatic gastric and gastroesophageal junction cancers shows long-term response under trastuzumab maintenance monotherapy. Obviously, HER2 status alone is not able to identify these patients. We
Autor:
Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required m
Externí odkaz:
https://doaj.org/article/76d82438b7e2457c9fd5fa68a566c022
Autor:
Tong Li, Beifang Li, Asgharpour Sara, Christine Ay, Wing Yan Leung, Yanquan Zhang, Yujuan Dong, Qiaoyi Liang, Xiang Zhang, Philip Weidner, Tobias Gutting, Hans-Michael Behrens, Christoph Röcken, Joseph JY Sung, Matthias P. Ebert, Jun Yu, Elke Burgermeister
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Docking protein-1 (DOK1) is a tumor suppressor frequently lost in malignant cells, however, it retains the ability to control activities of immune receptors in adjacent stroma cells of the tumor microenvironment. We therefore hypothesized that addres
Externí odkaz:
https://doaj.org/article/3b2f59a051114db6b9c4c22c27c04c0c
Autor:
Tobias, Gutting, Andreas, Merkel, David J, Fink, Svetlana, Hetjens, Philip, Weidner, Yanxiong, Yu, Georg, Kähler, Matthias P, Ebert, Timo, Gaiser, Elke, Burgermeister, Sebastian, Belle
Publikováno v:
Journal of Gastrointestinal and Liver Diseases. 30:446-455
Background and Aims: Colorectal adenomas are precursor lesions for colorectal cancer (CRC), a major cause of cancer-related death. Despite all molecular insights, there are still unknown variables in the development of CRC as well as uncertainties re
Autor:
Tobias Gutting, Christian A. Weber, Philip Weidner, Frank Herweck, Sarah Henn, Teresa Friedrich, Shuiping Yin, Julia Kzhyshkowska, Timo Gaiser, Klaus-Peter Janssen, Wolfgang Reindl, Matthias P. A. Ebert, Elke Burgermeister
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
To identify novel hubs for cancer immunotherapy, we generated C57BL/6J mice with concomitant deletion of the drugable transcription factor PPARγ and transgenic overexpression of the mutant KRASG12V oncogene in enterocytes. Animals developed epitheli
Externí odkaz:
https://doaj.org/article/4af5172de420432182bd5a1936ffaaae
Publikováno v:
Molecular Cancer Research. 21:B031-B031
The coiled coil domain of Myotubularin Related Protein 7 (MTMR7) and a peptide of the same sequence (M7CC) have been shown to have an anti-cancer effect via direct interaction with PPARγ (Weidner et al. 2020). The same studies also found an inhibiti
Autor:
Tianzuo Zhan, Philip Weidner, Nadine Schulte, Christoph Reissfelder, Lena Dreikhausen, Johannes Moersdorf, Sebastian Belle, Matthias P. Ebert
Publikováno v:
Visc Med
Pancreatic acinar cell carcinoma (ACC) is a rare malignant disease that displays distinct differences to pancreatic ductal adenocarcinoma. Here, we report the case of a patient with ACC and underlying breast cancer susceptibility gene 2 (BRCA2) germl
Autor:
MP Ebert, Timo Gaiser, Veronika Hauber, Tobias Gutting, Johannes Betge, Elke Burgermeister, Adelheid Cerwenka, Philip Weidner, Sebastian Belle
Publikováno v:
Viszeralmedizin 2021 Gemeinsame Jahrestagung Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), Sektion Endoskopie der DGVS, Deutsche Gesellschaft für Allgemein und Viszeralchirurgie (DGAV).
Autor:
Isabel Porth, Philip Weidner, Sylvie Lorenzen, Wilko Weichert, Thorsten Oliver Götze, Sven Perner, Kim Luley, Daniela Hirsch, Ralf-Dieter Hofheinz, Diana B. Peckys, Zahra Mostajeran, Niels de Jonge, Timo Gaiser
Publikováno v:
Cancer Research. 82:4018-4018
Since 2010, Trastuzumab combined with chemotherapy is the standard treatment for patients with HER2 (ERBB2) positive advanced or metastatic gastric and gastroesophageal junction cancer (GGEJ). While few patients show long-term response to the treatme