Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Philip, Seeman"'
Autor:
Hubert H. M. Van Tol, Pierre F. Spano, Pierre Sokoloff, David R. Sibley, Philip Seeman, Goran Sedvall, Jean-Charles Schwartz, Bernard Scatton, Kim A. Neve, Maria Cristina Missale, Saloman Z. Langer, John W. Kebabian, David K. Grandy, Raul R. Gainetdinov, Gilberto Fisone, Stefano Espinoza, Olivier Civelli, Marc G. Caron, Arvid Carlsson, Emiliana Borrelli, Jean-Martin Beaulieu
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Dopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Dopamine Receptors [373]) are commonly divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families, where the endogenous agonist is dopamine.
Publikováno v:
Parkinson's Disease, Vol 2014 (2014)
Background. It is known that ultra-low doses of haloperidol can cause dopamine supersensitivity of dopamine D2 receptors and related behaviour in animals. Objective. The objective was to determine whether a daily ultra-low dose of 40 micrograms of ha
Externí odkaz:
https://doaj.org/article/ea1de0e6d3f4403a9131664916f782f2
Publikováno v:
ACS Chem Neurosci
The dopamine D(2) receptor exists in two different states, D(2)(high) and D(2low); the former is the functional form of the D(2) receptor and associates with intracellular G-proteins. The D(2) agonist [(3)H]MCL-536 has high affinity for the D(2) rece
Publikováno v:
ACS Chem Neurosci
Increases in the D2 receptor high affinity state are associated with certain neurological disorders. We synthesized and characterized the high-affinity D2high ligand [(3)H]MCL-536 in competition binding against the D2/3 agonist R-(−)-N-n-propylnora
Autor:
Serdar Durdagi, Matthias Stein, Busecan Aksoydan, Philip Seeman, Ramin Ekhteiari Salmas, Mine Yurtsever, Isik Kantarcioglu, Ismail Erol
Publikováno v:
ACS Chemical Neuroscience
Dopamine receptor D2 (D2R) plays an important role in the human central nervous system and is a focal target of antipsychotic agents. The D2HighR and D2LowR dimeric models previously developed by our group are used to investigate the prediction of bi
Autor:
Mine Yurtsever, Matthias Stein, Serdar Durdagi, Busecan Aksoydan, Philip Seeman, Ramin Ekhteiari Salmas
Publikováno v:
ACS Chemical Neuroscience. 8:826-836
The dopamine D2 receptor (D2R) plays an important part in the human central nervous system and it is considered to be a focal target of antipsychotic agents. It is structurally modeled in active and inactive states, in which homodimerization reaction
Autor:
Hubert H.M. Van Tol, David R. Sibley, Jean-Charles Schwartz, Saloman Z. Langer, Kim A. Neve, John W. Kebabian, Jean-Martin Beaulieu, Arvid Carlsson, Marc G. Caron, Pierre Sokoloff, Pierre F. Spano, Olivier Civelli, Emiliana Borrelli, Maria Cristina Missale, Philip Seeman, Bernard Scatton, Raul R. Gainetdinov, Gilberto Fisone, Göran Sedvall, Stefano Espinoza, David K. Grandy
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Dopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Dopamine Receptors [363]) are commonly divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families, where the endogenous agonist is dopamine.
Autor:
Philip Seeman
Publikováno v:
Neuropsychopharmacology
Publikováno v:
Journal of chemical information and modeling. 58(4)
The active (D2
Publikováno v:
Journal of Chemical Information and Modeling
The active (D2HighR) and inactive (D2LowR) states of dimeric dopamine D2 receptor (D2R) models were investigated to clarify the binding mechanisms of the dopamine agonist bromocriptine, using Molecular Dynamics (MD) simulation. The aim of this compre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e9ca0e160d35888899f12d1885617
https://hdl.handle.net/21.11116/0000-0001-39EA-821.11116/0000-0002-8170-D
https://hdl.handle.net/21.11116/0000-0001-39EA-821.11116/0000-0002-8170-D