Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Philip, Savage"'
Autor:
Philip Savage, David Monk, Jose R. Hernandez Mora, Nick van der Westhuizen, Jennifer Rauw, Anna Tinker, Wendy Robinson, Qianqian Song, Michael J. Seckl, Rosemary A. Fisher
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemothera
Externí odkaz:
https://doaj.org/article/e9ed2f55274d433cb0846a7a58743447
Autor:
Philip Savage
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Cytotoxic DNA damaging chemotherapy brings clinical benefits in the treatment of many metastatic malignancies. However routine curative treatment remains restricted to a small number of malignancies including acute leukemia, high grade lymphoma, germ
Externí odkaz:
https://doaj.org/article/bef71bc6a744429bb761d9f52500dd45
Autor:
Sarah Mahmoud, Emily C. Mills, Mark P. Lythgoe, Jonathan Krell, Aishwarya Vasudevan, Philip Savage
Publikováno v:
Drug Discovery Today. 26:301-307
Analysis of new anticancer drugs licensed in the UK found that 44 new therapies were approved from 2015 to 2019. No other 5-year period has produced as many new therapies. Most new drugs are kinase inhibitors (KIs, N = 18) and monoclonal antibodies (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0faf4027953a3a0cafdf3def7a0f4a90
https://doi.org/10.1016/j.drudis.2020.11.011
https://doi.org/10.1016/j.drudis.2020.11.011
Autor:
Mark P. Lythgoe, Aakash Desai, Bishal Gyawali, Philip Savage, Jonathan Krell, Jeremy L. Warner, Ali Raza Khaki
Ensuring patients have access to safe and efficacious medicines in a timely manner is an essential goal for regulatory agencies, one which has particular importance in oncology because of the substantial unmet need for new therapies. The 2 largest re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf264ba66ee92b0efd526090060d874
http://hdl.handle.net/10044/1/97095
http://hdl.handle.net/10044/1/97095
Autor:
Dee Short, Giorgia Mangili, Gabriella Ferrandina, Adrian Lim, Giovanna Scarfone, Xianne Aguiar, Alice Bergamini, Michael J. Seckl, Sandro Pignata, Naveed Sarwar, Cristina Camnasio, Baljeet Kaur, Gennaro Cormio, Philip Savage
Publikováno v:
European Journal of Cancer. 137:136-143
Background The role of surveillance after surgery for stage IA-C grade 2 (G2) or grade 3 (G3) immature teratomas (ITs) is controversial with many guidelines advocating adjuvant chemotherapy. Here, we investigate the safety of surveillance in stage IA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73410665a37243777288d53e1a1e223
https://doi.org/10.1016/j.ejca.2020.06.033
https://doi.org/10.1016/j.ejca.2020.06.033
Autor:
Lawrence Simpson, Aspasia Soultati, Philip Savage, Jenna Bhimani, Lara Philipps, Mark P. Lythgoe, Andrew Webb
Publikováno v:
Journal of Oncology Pharmacy Practice. 26:93-98
Introduction Drug treatment for cancer has changed dramatically over the past decade with many new drugs often with multiple applications. More recently, the detailed pathway for approval from the National Institute for Health and Care Excellence (NI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a854df03a53c13c537b52ff6ff46b967
https://doi.org/10.1177/1078155219839445
https://doi.org/10.1177/1078155219839445
Autor:
Barry W. Hancock, Matthew C Winter, Rosemary A. Fisher, Philip Savage, E. Kanfer, John Tidy, Michael J. Seckl, Kam Singh, M M Frijstein, Christianne A.R. Lok, D Short, Naveed Sarwar
Publikováno v:
European Journal of Cancer. 109:162-171
The objective of the study was to evaluate the effect of high-dose chemotherapy (HDC) with peripheral blood stem cell support (PBSCS) on survival of patients with gestational trophoblastic neoplasia (GTN) with either refractory choriocarcinomas or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b169c72e3e69fd694e3629628529299
https://doi.org/10.1016/j.ejca.2018.12.033
https://doi.org/10.1016/j.ejca.2018.12.033
Autor:
Philip Savage
Publikováno v:
Expert Opinion on Orphan Drugs. 7:27-36
Introduction: Gestational Trophoblastic Neoplasia (GTN) are a group of rare malignancies arising from the cells of conception. GTN was the first metastatic cancer to be cured with chemotherapy and ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35725ee68625c196790fe1c15b87660c
https://doi.org/10.1080/21678707.2019.1559047
https://doi.org/10.1080/21678707.2019.1559047
Autor:
Giovanna Scarfone, Cristina Camnasio, Philip Savage, Michael J. Seckl, Gabriella Ferrandina, Giorgia Mangili, Adrian Lim, Xianne Aguiar, Alice Bergamini, Dee Short, Naveed Sarwar, Gennaro Cormio, Sandro Pignata, Baljeet Kaur
Publikováno v:
European journal of cancer (Oxford, England : 1990). 152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1078597ed533295faf5fa49e4f2c07
https://pubmed.ncbi.nlm.nih.gov/34099362
https://pubmed.ncbi.nlm.nih.gov/34099362
Autor:
Naveed Sarwar, R. Cortés-Charry, L. Hennah, Fieke E. M. Froeling, T. Tin, Xianne Aguiar, Philip Savage, Nick Unsworth, Richard J. Harvey, Dee Short, Michael J. Seckl, Baljeet Kaur
Publikováno v:
ESMO Open
Background A human chorionic gonadotropin (hCG) cut-off of ≤300 IU/l for starting actinomycin D (ActD) in post-molar gestational trophoblastic neoplasia (GTN) patients developing methotrexate resistance (MTX-R) reduced the number of women needing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460e1b22f6eb0307c281d9bb4f3e85be
http://europepmc.org/articles/PMC8044379
http://europepmc.org/articles/PMC8044379