Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Philip, Reigan"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Poly(A)-specific ribonuclease (PARN) is a 3′-exoribonuclease that removes poly(A) tails from the 3′ end of RNAs. PARN is known to deadenylate some ncRNAs, including hTR, Y RNAs, and some miRNAs and thereby enhance their stability by limi
Externí odkaz:
https://doaj.org/article/8b9f4079e632425a8c9b274470d90e0f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The septin family of eukaryotic proteins comprises distinct classes of sequence-related monomers that associate in a defined order into linear hetero-oligomers, which are capable of polymerizing into cytoskeletal filaments. Like actin and ⍺ and β
Externí odkaz:
https://doaj.org/article/de31782bf02b4e68b120fc152af918da
Publikováno v:
Molecules, Vol 28, Iss 19, p 6800 (2023)
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8. Additional analo
Externí odkaz:
https://doaj.org/article/8c074562c3ad478d806719d1f0a7c36d
Autor:
Dean Oldham, Hong Wang, Juliet Mullen, Emma Lietzke, Kayla Sprenger, Philip Reigan, Robert H. Eckel, Kimberley D. Bruce
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Lipoprotein lipase (LPL) plays a crucial role in preventing dyslipidemia by hydrolyzing triglycerides (TGs) in packaged lipoproteins. Since hypertriglyceridemia (HTG) is a major risk factor for cardiovascular disease (CVD), the leading cause of death
Externí odkaz:
https://doaj.org/article/be610773d3304fbb885e152a280d5da4
Autor:
Stanley M. Kanai, Caleb Heffner, Timothy C. Cox, Michael L. Cunningham, Francisco A. Perez, Aaron M. Bauer, Philip Reigan, Cristan Carter, Stephen A. Murray, David E. Clouthier
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin rec
Externí odkaz:
https://doaj.org/article/1018cf0b961340698266dbc93ce8cfff
Autor:
Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan, Devin A. Aldaz, Casey P. McDermott, Katriana A. Popichak, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant research efforts, treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that increase host defense to the virus. Replication of SARS-CoV-2
Externí odkaz:
https://doaj.org/article/042ff2a87d9a449d818ce9b18173369f
Autor:
Becka M. Warfield, Kimberly A. Casalvieri, Christopher J. Matheson, Donald S. Backos, Philip Reigan
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107433- (2021)
The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target. The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer proces
Externí odkaz:
https://doaj.org/article/059415eeb00549beade6c15ccf59852c
Autor:
Lindsay W. Brubaker, Donald S. Backos, Vu T. Nguyen, Philip Reigan, Tomomi M Yamamoto, Elizabeth R. Woodruff, Ritsuko Iwanaga, Michael F. Wempe, Vijay Kumar, Christianne Persenaire, Zachary L. Watson, Benjamin G. Bitler
Publikováno v:
Expert Opinion on Therapeutic Targets. :1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05bb72902b5fcb68b31e7422a9211081
https://doi.org/10.1080/14728222.2023.2218614
https://doi.org/10.1080/14728222.2023.2218614
Publikováno v:
Data in Brief, Vol 29, Iss , Pp - (2020)
The data have been obtained for a series of substituted pteridinones and pyrimidines that were developed based on BI-D1870 to establish a structure-activity relationship for RSK inhibition. The 19 compounds, 12 of these with R- and S-isomeric forms,
Externí odkaz:
https://doaj.org/article/b5de852ad7dd4c74afc24b17e46b7a6b
Autor:
Becka M. Warfield, Philip Reigan
Publikováno v:
Trends in Cancer. 8:482-493
Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication. In many cancers TP is expressed at high levels and promotes thymidine catabolism, ultimately generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392902bf8708b6f23f581e9b0afc7f61
https://doi.org/10.1016/j.trecan.2022.01.018
https://doi.org/10.1016/j.trecan.2022.01.018