Patient-reported well-being in value-based care using tildrakizumab in a real-world setting: protocol of a multinational, phase IV, 1-cohort prospective observational study (the POSITIVE study)

Autor: Matthias Augustin, Esteban Dauden, Sascha Gerdes, Philip Laws, Ulrich Mrowietz, Rachel Sommer, Elke de Jong, Gabriella Fabbrocini, Luigi Naldi, Alexander Navarini, Jo Lambert, Ziad Reguiai, Eric Massana, Teresa Obis, Ismail Kasujee

Publikováno v: BMJ Open, Vol 13, Iss 2 (2023)

Introduction Psoriasis is a chronic inflammatory skin disease that negatively impacts the quality of life of patients and their families. However, the most commonly used decision-making tools in psoriasis, Psoriasis Area and Severity Index (PASI), Ph

Externí odkaz: https://doaj.org/article/35bffeaf57d44e4c8b69ef631470b57e

P018 Non-alcoholic fatty liver disease in spondyloarthritis: identifying patients on therapy at high risk of serious liver disease

Autor: Stephanie R Harrison, Udvitha Nandasoma, Richard Parker, Chenchu Chimakurthi, Philip Laws, Andrew Barr, Claire Vandevelde, Helena Marzo-Ortega, Jane Freeston

Publikováno v: Rheumatology. 62

Background/Aims People with Spondyloarthritis (SpA), especially those with psoriatic disease (PsD) [psoriasis (PsO) and psoriatic arthritis (PsA)], are at higher risk of non-alcoholic fatty liver disease (NAFLD) due to increased prevalence of metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd44abcc461164b5b97a6487b9fb36c7
https://doi.org/10.1093/rheumatology/kead104.060

IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis

Autor: Charlie Bridgewood, Gareth W. Fearnley, Anna Berekmeri, Philip Laws, Tom Macleod, Sreenivasan Ponnambalam, Martin Stacey, Anne Graham, Miriam Wittmann

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis. This research

Externí odkaz: https://doaj.org/article/18b2841b2c65416fa826a005d1348c64

Genetic interaction between placental growth factor and vascular endothelial growth factor A in psoriasis

Autor: I. D. Kamaly‐Asl, Philip Laws, Helen S. Young, P. Pemberton, Christopher E.M. Griffiths

Publikováno v: Clinical and Experimental Dermatology
Young, H S, Kamaly-asl, I D, Laws, P M, Pemberton, P & Griffiths, C E M 2019, ' Genetic interaction between placental growth factor and vascular endothelial growth factor A in psoriasis ', Clinical and Experimental Dermatology . https://doi.org/10.1111/ced.14102

Summary Background Expression of vascular endothelial growth factor A (VEGFA) is increased in chronic inflammatory skin diseases, including psoriasis, and loci for two VEGFA single nucleotide polymorphisms are associated with early‐onset psoriasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1df6756494c9e64a6048c7031158cbb
https://doi.org/10.1111/ced.14102

Risks of basal cell and squamous cell carcinoma in psoriasis patients after treatment with biologic vs non-biologic systemic therapies

Autor: Josh Richards, Marilyn Benham, Ian Evans, M.M. Soliman, Anthony Ormerod, Adèle C. Green, Tess McPherson, Nick J. Reynolds, C. M. Owen, Eleanor Pearson, Sagair Hussain, Philip Laws, Jonathan Barker, Christopher E.M. Griffiths, Linda Lawson, Teena Mackenzie, Catherine H. Smith, K.J. Mason, A D Burden, C.E. Kleyn, Ruth Murphy, Fiona Browne, Haibat Ali, Kathleen McElhone, Brian Kirby, Richard B. Warren, Mark Lunt

Publikováno v: Journal of the European Academy of Dermatology and Venereology : JEADVReferences. 35(8)

There are concerns that immunomodulatory therapies may increase the risks of developing basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) in patients with moderate-severe psoriasis. A systematic review showed that psoriasis patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bf74ba2512bd29d4d224a1d631c781
https://pubmed.ncbi.nlm.nih.gov/33866626