Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Philip, Horx"'
Autor:
Philip Horx, Armin Geyer
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230962 (2020)
A designed disulfide-rich β-hairpin peptide that dimerizes spontaneously served as a hinge-type connection between proteins. Here, we analyze the range of dynamics of this hinge dimer with the aim of proposing new applications for the DNA-encodable
Externí odkaz:
https://doaj.org/article/5dc1b7408c7a446a8be73fabc7779b1c
Autor:
Philip Horx, Armin Geyer
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
A pair of intermolecular disulfide bonds connecting two protein domains restricts their relative mobility in a systematic way. The bi-disulfide hinge cannot rotate like a single intermolecular disulfide bond yet is less restrained than three or more
Externí odkaz:
https://doaj.org/article/e341832847d24a1c9b320dea2e8b3c43
Autor:
Philip Horx, Armin Geyer
Publikováno v:
Chemical Science
The elucidation of internal dynamics in proteins is essential for the understanding of their stability and functionality. Breaking the symmetry of the degenerate rotation of the phenyl side chain provides additional structural information and allows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199db8abcbe9c36803f9166ddf049dae
https://doi.org/10.1039/d1sc02346b
https://doi.org/10.1039/d1sc02346b
Publikováno v:
Chembiochem
A generalized synthetic strategy is proposed here for the synthesis of asymmetric β‐indoylated amino acids by 8‐aminoquinoline (8AQ)‐directed C(sp3)‐H functionalization of suitably protected precursors. Peptides containing one of the four st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70664880c0d429e0ae2fd5a2d2e204e9
https://doi.org/10.1002/cbic.202000424
https://doi.org/10.1002/cbic.202000424
Autor:
Philip Horx, Friederike Danneberg, Robert Berger, Elisabeth Kalden, Felix Zellmann, Hauke Westemeier, Abdullah Akpinar, Michael W. Göbel, Kathrin Dörr, Mirco Zeiger
2-Aminobenzimidazole 10, although a weak catalyst in the monomeric state, is a successful building block for effective artificial ribonucleases. In an effort to identify new building blocks with improved catalytic potential, RNA cleavage by a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ad9f50d54190a04b85cd9f44368b1e
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64107
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64107
Publikováno v:
Chemical Science. 10:8634-8641
The 8-aminoquinoline (8AQ) directed C(sp3)-H functionalization was applied in the synthesis of β-arylated tryptophan derivatives. The laborious protecting group reorganization towards α-amino acids compatible for solid phase peptide synthesis (SPPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a0979a1fbd9b73b40adeafeff295e9
https://doi.org/10.1039/c9sc03440d
https://doi.org/10.1039/c9sc03440d
Publikováno v:
Chemical Science
The aminoquinoline-directed C–H activation was used to synthezise unnatural tryptophans for solid phase peptide synthesis for the first time.
The 8-aminoquinoline (8AQ) directed C(sp3)–H functionalization was applied in the synthesis of β-a
The 8-aminoquinoline (8AQ) directed C(sp3)–H functionalization was applied in the synthesis of β-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3873b12de1e249fcbefe411dedcda72
https://pubmed.ncbi.nlm.nih.gov/31803437
https://pubmed.ncbi.nlm.nih.gov/31803437
Publikováno v:
Journal of Peptide Science. 24:e3075
Maleimide-thiol coupling is a popular bioconjugation strategy, but little is known about the stereoselectivity and the stereodynamics of the succinimide thioether formed in a biopolymer environment. We used thiol 1,4-addition for the macrocyclisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09ccfae4d78c9f017450236af4e18c6
https://doi.org/10.1002/psc.3075
https://doi.org/10.1002/psc.3075