Výsledky vyhledávání - "Philip, East"

Akademický článek

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Autor: Philip East, Gavin P. Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, TRACERx consortium, Julian Downward, Sophie de Carné Trécesson

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other s

Externí odkaz: https://doaj.org/article/e3cb67ca01f3408eabbb55aee891fb90

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Akademický článek

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Autor: Luca Guglielmi, Claire Heliot, Sunil Kumar, Yuriy Alexandrov, Ilaria Gori, Foteini Papaleonidopoulou, Christopher Barrington, Philip East, Andrew D. Economou, Paul M. W. French, James McGinty, Caroline S. Hill

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signal

Externí odkaz: https://doaj.org/article/c3a7ce8f93434e77b3526dc4eb45c12f

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Akademický článek

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Autor: Anett Jandke, Daisy Melandri, Leticia Monin, Dmitry S. Ushakov, Adam G. Laing, Pierre Vantourout, Philip East, Takeshi Nitta, Tomoya Narita, Hiroshi Takayanagi, Regina Feederle, Adrian Hayday

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Butyrophilin-like genes are emerging as central to tissue associated γδ T cell compartments. Here, the authors show that the butyropilin-like gene-products exert their effects as combinatorially diverse heteromers that differentially affect the sel

Externí odkaz: https://doaj.org/article/c213401a85c342bf9b8247f63d992ad0

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