Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma – protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial

Autor: Khalid Hamandi, Julie Woodfield, Smriti Agarwal, Richard Edwards, John Williamson, Ravindran Visagan, Rustam Al-Shahi Salman, Howard Brydon, Diederik Bulters, Dawn Hennigan, Paul Leach, Conor Mallucci, Nitin Mukerji, Marios Papadopoulos, Nicholas Ross, Martin Tisdall, Carole Turner, Shungu Ushewokunze, Raghu Vindlacheruvu, Paul Brennan, Phil White, Sophie Hunter, Karen Coy, Julia Wade, James Stewart, Tom Hughes, Laura Forsyth, Kirsty Harkness, David White, Rupal Shah, Sanjay Bhate, Neil Kitchen, Peter J Hutchinson, Emanuel Cirstea, Ramesh Nair, Rebecca Hall, Varduhi Cahill, Tom Hayton, Silvia Tarantino, Christin Eltze, Jack Lee, Arlo Whitehouse, Daniel Walsh, Jacqueline Stephen, Nicola Phillips, Steff Lewis, Susan Davies, Mathew Guilfoyle, Peter S Hall, Andrew Stoddart, Francesca Colombo, Emma Richards, Greg James, Sarah Illingworth, William B Lo, Andrew Bacon, Vijeya Ganesan, Sabina Patel, Aileen R Neilson, Felicia Jennings, Saba Raza-Knight, Andrew Brodbelt, Aswin Chari, Hasan Asif, Ian Kamaly-Asl, Milan Makwana, Zubair Tahir, Allan MacRaild, Grace Vassallo, Ian Anderson, Daniel Holsgrove, Carole Chambers, Sandra Williams, Francesca Spickett-Jones, Marios C Papadopoulos, John Preston, Edward White, Adel Helmy, Sarah Ali, John Reid, Daniel Brown, Louis Taylor, Christopher Uff, Patrick Grover, Azra Banaras, Linetty Makawa, Anil Israni, Richard J Edwards, William Muirhead, Daniel Brooks, Debbie Brown, Ciaran Scott Hill, Kerry Smith, Beth Atkinson, Michelle Fawcett, Sifelani Tshuma, Oliver Kennion, Jo Howe, James J M Loan, Philip Clatworthy, Claire Hudson, Rebecca Hodnett, Madalina Roman, Mary Sikaonga, Elaine Kinsella, Mario Teo, Venetia Giannakaki, James Loan, Lauren Harris, Jack Wildman, Emmanuel Chavredakis, Nihal Gurusinghe, Alex Rossdeutsch, Anthony Wiggins, Giannis Sokratous, Lucie Ferguson, Shakeelah Patel, Sonia Raj, Oishik Raha, Janneke van Beijnum, Pragnesh Bhatt, Anna Bjornson, Nicole Broomes, Alistair Bullen, Julian Cahill, Mihai Danciut, Ronneil Digpal, Ioannis Fouyas, Lauren S Harris, Sohail Majeed, Matthias Radatz, Oliver Wroe Wright, Jessica Teasdale, Michelle Coakley, Drahoslav Sokol, Chandru Kaliaperumal, Mairi MacDonald, Sarah Risbridger, Siobhan Kearney, Ellaine Bosetta, Thomas Doke, Sonny Coskuner, Christine Kamara, Jonathan Gardner, Imron Hamina, Kishor Chaudhari, Liliana Chapas, Karen Caldwell, Sarah Holland, Tamara Tajsic, Rachael Dore, Taya Anderson, Shelley Mayor, Laura O'Malley, Samantha Glover, Janice Irvine, Annika Walch, Farah Muir, Eng Tah Goh, Andrew McDarby, Michelle Bates, Rebecca Hancox, Claudia Kate Auyeung, Elizabeth Goff, Deanna Stephens, Borislava Borislavova, Ruth Worner, Sandeep Buddha, Lisa Tucker, Sandra Dymond, Andrew Mallick, Dymona McAleer, Belinda Gunning, Emma Clarkson, Cathy Stoneley, Jibril Osman Farah, Niamh Bohnacker, Rosette Marimon, Lydia Parker, Puneet Sharma, Dan Holsgrove, Danielle McLaughlan, Tracey Marsden, Kathryn Cawley, Hellen Raffalli, Imedla Mayor, Dipek Ram, Rebecca Keeping, Katie Hennessy, Ammar Kadhim, Md Moidul Islam, Manjunath Prasad, Cheryl Webster, Vicky Slater, Saffnan Mohamed, Saba Raza Knight, Terri-Louise Cromie, Allan Brown, Ruth Pennington, Charlene Campbell, Anthony Ghosh, Teresa Fitzpatrick, Mohammed Patel, Winnington Ruiz, Mirriam Taylor, Divina Anyog, Katarzyna Tluchowska, Jackson Nolasco, Kleopatra Angelopoulou, Bethany Welch, Ida Ponce, Lucy Bailey, Mia Marsden, Angelene Cope, Deepthy Blesson, Rachel Sutton, Mary Kambafwile, Jade McAndrew

Publikováno v: BMJ Open, Vol 13, Iss 8 (2023)

Introduction The top research priority for cavernoma, identified by a James Lind Alliance Priority setting partnership was ‘Does treatment (with neurosurgery or stereotactic radiosurgery) or no treatment improve outcome for people diagnosed with a

Externí odkaz: https://doaj.org/article/df389aa5a29f4557ac19c817e505e753

A Comparison of T Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study

Autor: Bryony L McGarry, Robin A Damion, Isabel Chew, Michael J Knight, George WJ Harston, Davide Carone, Peter Jezzard, Amith Sitaram, Keith W Muir, Philip Clatworthy, Risto A Kauppinen

Publikováno v: Journal of Central Nervous System Disease, Vol 12 (2020)

Background: T 2 relaxation-based magnetic resonance imaging (MRI) signals may provide onset time for acute ischemic strokes with an unknown onset. The ability of visual and quantitative MRI-based methods in a cohort of hyperacute ischemic stroke pati

Externí odkaz: https://doaj.org/article/8f88fa2eeb60427c914889ef86dc3b8f

Working Memory Impairment in Transient Ischaemic Attack:N-back as a Sensitive Measure for Detection

Autor: Laura J. Smith, Polly Gregory, Philip Clatworthy, Lucy Gallop, George Stothart

Publikováno v: Smith, L J, Gregory, P, Clatworthy, P, Gallop, L & Stothart, G 2021, ' Working Memory Impairment in Transient Ischaemic Attack : N-back as a Sensitive Measure for Detection ', Brain Impairment . https://doi.org/10.1017/BrImp.2021.25

Background:Transient ischaemic attack (TIA) can lead to lasting changes in brain structure and function resulting in cognitive impairment. Cognitive screening tools may lack sensitivity for detecting cognitive impairments, particularly executive func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1febbe4039811184d7673e6540c0cd7a
https://purehost.bath.ac.uk/ws/files/228503276/Smith_et_al._TIA_WMem_BIM_2021_0018.R3_clean_.pdf

Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study

Autor: Richard J Perry, Arina Tamborska, Bhagteshwar Singh, Brian Craven, Richard Marigold, Peter Arthur-Farraj, Jing Ming Yeo, Liqun Zhang, Ghaniah Hassan-Smith, Matthew Jones, Christopher Hutchcroft, Esther Hobson, Dana Warcel, Daniel White, Phillip Ferdinand, Alastair Webb, Tom Solomon, Marie Scully, David J Werring, Christine Roffe, Sara Al-izzi, Aravindhan Baheerathan, Soma Banerjee, Gary Benson, Claudia Boshier, Sandeep Buddha, Nathan Burley, Ruaridh Cameron Smail, Arvind Chandratheva, Pavel Chudakou, Philip Clatworthy, Alasdair Coles, Thomas Cox, Ranjit Dasgupta, Richard Davenport, Darrell Devine, Stephen Fenlon, Carolyn Gabriel, Rita Ghatala, Claire Hall, Milan Hargovan, Kirsty Harkness, Ian Harvey, Lucy Hicken, Laura Howaniec, Abubaker Ibnouf, Luis Idrovo, Gordon Ingle, Yong Kyan Lee, Ailidh Lang, Simon McBride, Malcolm McLeod, Ruth Medlock, Puja Mehta, Ian Morrison, Girish Muddegowda, Sharon Muzerengi, Donald Pang, Gopinath Periyasamy, Gavin Preston, Naomi Priestley, Lydia Revicka, Sadia Saber, Elliott Smith, Youssef Sorour, Oliver Spooner, Jon Stone, Laszlo Sztriha, Narmathey Thambirajah, Rhys Thomas, David Veale, Jasmine Wall, Sarah White, James White, Syarah Yusoff, Laura Zambreanu

Publikováno v: Lancet (London, England)
LANCET

Background: A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd9fef3e16362f6577bc8d3cd07ae55
https://www.repository.cam.ac.uk/handle/1810/327808

Sneddon Syndrome: A Case Report Exploring the Current Challenges Faced with Diagnosis and Management

Autor: Keith Miller, Harsha Gunawardena, Mario Teo, Jonathan Cleaver, Philip Clatworthy, Shelley Renowden

Publikováno v: Case Reports in Neurology
Case Reports in Neurology, Vol 11, Iss 3, Pp 357-368 (2019)

Sneddon syndrome (SS) is a rare medium-vessel vasculopathy which characteristically presents with livedo racemosa (LR) and complications such as strokes. This case report describes a female presenting acutely with a stroke and, initially, no evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1473ab03ae64b242f568aa9ddf8652
https://doi.org/10.1159/000503955