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Akademický článek

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primatesResearch in context

Autor: Elise Ishida, Devin T. Corrigan, Tingting Chen, Yanyan Liu, Ryung S. Kim, Lusheng Song, Tara M. Rutledge, D Mitchell Magee, Joshua LaBaer, Todd L. Lowary, Philana Ling Lin, Jacqueline M. Achkar

Publikováno v: EBioMedicine, Vol 99, Iss , Pp 104897- (2024)

Summary: Background: Increasing evidence supports that antibodies can protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially in the airways, is limited. The main objective of this study was to identify a

Externí odkaz: https://doaj.org/article/4a9a42baaad14733a7cf3cdf00f2652e

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Additional file 3: of Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure

Autor: Cadena, Anthony, Yixuan Ma, Ding, Tao, MacKenzie Bryant, Maiello, Pauline, Geber, Adam, Philana Lin, JoAnne Flynn, Ghedin, Elodie

Figure S3. Relative abundance of main taxa in the lung microbiota. For most monkeys, the microbial composition is relatively similar between right and left lobes within the same monkey, while the microbiota across monkeys is divergent. b: baseline; 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a09fd63130028a92ef52e926b711c3c6

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Akademický článek

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.

Autor: Maral Budak, Joseph M Cicchese, Pauline Maiello, H Jacob Borish, Alexander G White, Harris B Chishti, Jaime Tomko, L James Frye, Daniel Fillmore, Kara Kracinovsky, Jennifer Sakal, Charles A Scanga, Philana Ling Lin, Véronique Dartois, Jennifer J Linderman, JoAnne L Flynn, Denise E Kirschner

Publikováno v: PLoS Computational Biology, Vol 19, Iss 6, p e1010823 (2023)

Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization initiated an End TB Strategy that aims to reduce TB-related deaths in 2035 by 95%. Recent r

Externí odkaz: https://doaj.org/article/6c3730d6ea76411e8f9be1bff53e7a93

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Akademický článek

Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas

Autor: Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O’Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn

Publikováno v: mBio, Vol 14, Iss 3 (2023)

ABSTRACT Despite the extensive research on CD4 T cells within the context of Mycobacterium tuberculosis (Mtb) infections, few studies have focused on identifying and investigating the profile of Mtb-specific T cells within lung granulomas. To facilit

Externí odkaz: https://doaj.org/article/0bd7932b650b4c48833d648c0ad5e9a1

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Predicting vaccine efficacy against tuberculosis using immunologic and radiologic measures in the non-human primate model

Autor: Robert M DiFazio, Pauline Maiello, Jaime Tomko, Lonnie Frye, Carolyn Bigbee, Chelsea Chedrick, Cassaundra Updike, Philana Lin, Else Marie Agger, Peter Andersen, JoAnne L Flynn

Publikováno v: The Journal of Immunology. 196:146.20-146.20

The only licensed vaccine (BCG) for tuberculosis (TB) has variable efficacy and does not protect against pulmonary TB. New vaccines are in development and in human clinical trials. However, vaccine trials are long and expensive without useful surroga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::111244be808d903ebf2ac3eab0c1c1ab
https://doi.org/10.4049/jimmunol.196.supp.146.20

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Blood transcriptional signatures of early tuberculosis infection and disease in cynomolgus macaque model (MPF6P.658)

Autor: Hannah Gideon, Jason Skinner, JoAnne Flynn, Philana Lin

Publikováno v: The Journal of Immunology. 194:202.16-202.16

Mycobacterium tuberculosis (Mtb) remains one of the successful human bacterial pathogen, yet little is known about the factors that influence infection outcome. The Cynomolgus macaque model of tuberculosis (TB) recapitulates many of the manifestation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1f59d80379c60e4938030f228bf8cea
https://doi.org/10.4049/jimmunol.194.supp.202.16

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Akademický článek

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

Autor: Nicole L. Grant, Pauline Maiello, Edwin Klein, Philana Ling Lin, H. Jacob Borish, Jaime Tomko, L. James Frye, Alexander G. White, Denise E. Kirschner, Joshua T. Mattila, JoAnne L. Flynn

Publikováno v: Cell Reports, Vol 39, Iss 7, Pp 110826- (2022)

Summary: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB. Immunologic investigation of lung granulomas is essential for understanding host c

Externí odkaz: https://doaj.org/article/27d79ee8867c4472a720d0e7466b5302

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Limited frequency of cytokine-producing T cells in tuberculosis lung granulomas (MPF6P.736)

Autor: Hannah Gideon, Amy Myers, JiaYao Phuah, Tara Rutledge, Teresa Coleman, Pauline Maiello, Philana Lin, JoAnne Flynn

Publikováno v: The Journal of Immunology. 192:195.5-195.5

Lung granulomas are the pathologic hallmark of Tuberculosis (TB). T cells are a major cellular component of tuberculosis lung granulomas and are known to play an important role in containment and progression of Mtb infection. We used cynomolgus macaq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7c022f1753d77413949359e7a600f5e
https://doi.org/10.4049/jimmunol.192.supp.195.5

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