Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Phil W. Yates"'
Autor:
Yueying Liu, Craig E. Crosson, Mohammad Dahrouj, Zsolt Ablonczy, Danielle Desjardins, Phil W. Yates
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Diabetic macular edema (DME), an accumulation of fluid in the subretinal space, is a significant cause of vision loss. The impact of diabetes on the breakdown of the inner blood-retina barrier (BRB) is an established event that leads to DME.
Autor:
Billie Key, Michael Victor Voronkov, Michael J. Crist, N. Andrew Whitlock, Beth McKnight, Suma Gopinathan, Gardyan Michael Walter, Kun Jian Gu, Bryce Alden Harrison, Zheng Y. Almstead, Craig E. Crosson, Ross Mabon, Dennis S. Rice, Phil W. Yates, Alan G. E. Wilson, Jason Allen, Nita Patel, Ying Liu, Brian D. Hamman, David B. Rawlins, Qingyun Liu, Yulian Zhang, Lawrence F. Courtney, Julia Zhou, S. David Kimball
Publikováno v:
Journal of medicinal chemistry. 52(21)
The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induc
Autor:
Bryce A. Harrison, N. Andrew Whitlock, Michael V. Voronkov, Zheng Y. Almstead, Kun-jian Gu, Ross Mabon, Michael Gardyan, Brian D. Hamman, Jason Allen, Suma Gopinathan, Beth McKnight, Mike Crist, Yulian Zhang, Ying Liu, Lawrence F. Courtney, Billie Key, Julia Zhou, Nita Patel, Phil W. Yates, Qingyun Liu
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 21, p6515-6518, 4p