Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Phil Tombleson"'
Autor:
Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E Comeau, Carl D Langefeld, Deborah S Cunninghame Graham, David L Morris, Timothy J Vyse
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010253 (2022)
Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with severe COVID-19 is correlated with that of systemic lupus erythematosus (SLE), having formally
Externí odkaz:
https://doaj.org/article/a5da860cf869428e9d470798b580693c
Autor:
Xuejun Zhang, Lingyan Chen, Deborah S. Cunninghame Graham, Wangling Yang, David L. Morris, Yong-Fei Wang, Lu Liu, Adrianna Bielowka, Phil Tombleson, Christopher A. Odhams, Rahell Ahmed, Huoru Zhang, Amy L. Roberts, Timothy J. Vyse
Publikováno v:
Chen, L, Wang, Y F, Liu, L, Bielowka, A, Ahmed, R, Zhang, H, Tombleson, P, Roberts, A L, Odhams, C A, Cunninghame Graham, D S, Zhang, X, Yang, W, Vyse, T J & Morris, D L 2020, ' Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity ', Human Molecular Genetics, vol. 29, no. 10, ddaa030, pp. 1745-1756 . https://doi.org/10.1093/hmg/ddaa030
Human Molecular Genetics
Human Molecular Genetics
ObjectiveUsing three European and two Chinese genome-wide association studies (GWAS), we investigated the performance of genetic risk scores (GRS) for predicting the susceptibility and severity of Systemic lupus erythematosus (SLE), using renal disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefcb199a1e215a418b77741f7f46f24
De novo mutations implicate novel genes with burden of rare variants in Systemic Lupus Erythematosus
Autor:
Phil Tombleson, Timothy J. Vyse, Myles Lewis, Ulrika Liljedahl, Simpson, Venu Pullabhatla, Amy L. Roberts, Ann-Christine Syvänen, Emanuele de Rinaldis, Daniele Mauro, Simon Vyse, Christopher A. Odhams, Sascha Sauer, David L. Morris
The omnigenic model of complex diseases stipulates that the majority of the heritability will be explained by the effects of common variation on genes in the periphery of core disease pathways. Rare variant associations, expected to explain far less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002dcf1be85bf3680888c02e6ad68203