Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Phil S. Sherman"'
Publikováno v:
Synapse. 45:31-37
We recently reported the synthesis and binding affinity of ligands for the muscarinic acetylcholine receptor (mAChR) based on both the pyrrolidyl and piperidyl benzilate scaffold. One of these, (R)-3-pyrrolidyl benzilate, was successfully radiolabele
Publikováno v:
Nuclear Medicine and Biology. 28:753-759
We have developed PET radioligands for the muscarinic acetylcholine receptor designed to be sensitive to endogenous acetylcholine changes. These radioligands were based on the piperidyl and pyrrolidyl benzilate scaffold and include (R)-N-(2-[18F]fluo
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 21(2)
Top of pageAbstract Although the inhibition of acetylcholinesterase remains the primary treatment of Alzheimer's disease, little is known of the results of increased acetylcholine levels on muscarinic receptor occupancy or function. Using N-(2-[18F]f
Autor:
Marc B. Skaddan, Tim J. Desmond, Phil S. Sherman, Michael R. Kilbourn, Scott E. Snyder, Kirk A. Frey
Publikováno v:
Journal of medicinal chemistry. 43(23)
A series of 31 compounds based on the piperidyl or pyrrolidyl benzilate scaffold were prepared from methyl benzilate and 4-piperidinol, (R)-(+)-3-piperidinol, or (R)-(+)-3-pyrrolidinol. Amine substituents included alkyl and aralkyl groups. In vitro K
Autor:
David E. Kuhl, James E. Carey, Michael S. Haka, Gary D. Hutchins, Phil S. Sherman, Michael R. Kilbourn, Robert A. Koeppe
Publikováno v:
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 16(6)
The in vivo charactersitics of a new radiotracer, [ 18 F]GBR 13119, have been examined. Full body biodistribution in rats has been determined and the expected human dosimetry calculated. Pharmacological specificity of in vivo regional brain distribut
Regional brain distribution of [18F]GBR 13119, a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice
Publikováno v:
European journal of pharmacology. 166(2)
We have examined the regional brain distribution of [18F]GBR 13119 (18F: beta +, T1/2 = 110 min), a dopamine uptake inhibitor, in CD-1 and C57BL/6 mice. High levels of binding are observed in the striatum of both species, with striatum/cerebellum rat