Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Phil S. Baran"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Radical substitution is a useful method to functionalize heterocycles, as in the venerable Minisci reaction. Empirically observed regiochemistries indicate that the CF2H radical has a nucleophilic character similar to alkyl radicals, but the
Externí odkaz:
https://doaj.org/article/56af02b631f7408ca2251b2243d98d92
Autor:
Kyle W. Knouse, Dillon T. Flood, Julien C. Vantourout, Michael A. Schmidt, Ivar M. Mcdonald, Martin D. Eastgate, Phil S. Baran
Publikováno v:
ACS Central Science, Vol 7, Iss 9, Pp 1473-1485 (2021)
Externí odkaz:
https://doaj.org/article/5be940581fe646b0a5177709e009d3a1
Autor:
Dillon T. Flood, Kyle W. Knouse, Julien C. Vantourout, Seiya Kitamura, Brittany B. Sanchez, Emily J. Sturgell, Jason S. Chen, Dennis W. Wolan, Phil S. Baran, Philip E. Dawson
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1789-1799 (2020)
Externí odkaz:
https://doaj.org/article/12ae8508ce774e0b8a11a1d9927f9ecb
Publikováno v:
Journal of the American Chemical Society. 145:11518-11523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075cb6fff216e4bc33533081c0e8cb88
https://doi.org/10.1021/jacs.3c03337
https://doi.org/10.1021/jacs.3c03337
Autor:
Yuta Hioki, Matteo Costantini, Jeremy Griffin, Kaid C. Harper, Melania Prado Merini, Benedikt Nissl, Yu Kawamata, Phil S. Baran
Publikováno v:
Science. 380:81-87
The Kolbe reaction forms carbon-carbon bonds through electrochemical decarboxylative coupling. Despite more than a century of study, the reaction has seen limited applications owing to extremely poor chemoselectivity and reliance on precious metal el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff6b16f57f994f735bf3c58d6644a94
https://doi.org/10.1126/science.adf4762
https://doi.org/10.1126/science.adf4762
Publikováno v:
The Journal of Organic Chemistry. 88:4387-4396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec7ed9cb5e5395bb7e62125d9183b8a
https://doi.org/10.1021/acs.joc.2c02993
https://doi.org/10.1021/acs.joc.2c02993
Autor:
Christopher G. Parker, Christian A. Kuttruff, Andrea Galmozzi, Lars Jørgensen, Chien-Hung Yeh, Daniel J. Hermanson, Yujia Wang, Marta Artola, Steven J. McKerrall, Christopher M. Josyln, Bjarne Nørremark, Georg Dünstl, Jakob Felding, Enrique Saez, Phil S. Baran, Benjamin F. Cravatt
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1276-1285 (2017)
Externí odkaz:
https://doaj.org/article/d8fe5f4438fc4026ad18baa35d2de81f
Autor:
Maximilian D. Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins S. Oderinde, Tamara El-Hayek Ewing, Philippe N. Bolduc, TeYu Chen, Hao Zhang, Peter T. W. Cheng, Benxiang Zhang, Michael D. Mandler, Vanna D. Blasczak, Jeremy M. Richter, Michael R. Collins, Ryan L. Schioldager, Martin Bravo, T. G. Murali Dhar, Benjamin Vokits, Yeheng Zhu, Pierre-Georges Echeverria, Michael A. Poss, Scott A. Shaw, Sebastian Clementson, Nadia Nasser Petersen, Pavel K. Mykhailiuk, Phil S. Baran
Publikováno v:
Journal of the American Chemical Society. 144:17709-17720
A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag-Ni electrocatalytic platform to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819a89b6a46fa50243f166fcbe5654d1
https://doi.org/10.1021/jacs.2c08006
https://doi.org/10.1021/jacs.2c08006
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1413-1420
Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C-C bonds by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c49c524fa313628e3fd71cc72bae07
https://doi.org/10.1021/acsmedchemlett.2c00286
https://doi.org/10.1021/acsmedchemlett.2c00286
Autor:
You-Chen Lin, Fabian Schneider, Kelly J. Eberle, Debora Chiodi, Hugh Nakamura, Solomon H. Reisberg, Jason Chen, Masato Saito, Phil S. Baran
Publikováno v:
Journal of the American Chemical Society. 144:14458-14462
A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion. Key transformations include two atroposelective Larock-based mac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea7939a6f7c5118e6f9934070ad2040
https://doi.org/10.1021/jacs.2c05892
https://doi.org/10.1021/jacs.2c05892